Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3545655..3546217 Replicon chromosome
Accession NZ_CP065032
Organism Serratia sp. CMO1

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag IT763_RS16960 Protein ID WP_025303801.1
Coordinates 3545655..3546011 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag IT763_RS16965 Protein ID WP_004936539.1
Coordinates 3546008..3546217 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT763_RS16940 3541391..3542188 - 798 WP_143778435.1 energy transducer TonB -
IT763_RS16945 3542291..3543130 - 840 WP_164053732.1 ChaN family lipoprotein -
IT763_RS16950 3543308..3544717 + 1410 WP_049299547.1 S-methylmethionine permease -
IT763_RS16955 3544707..3545645 + 939 WP_206194864.1 homocysteine S-methyltransferase -
IT763_RS16960 3545655..3546011 - 357 WP_025303801.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
IT763_RS16965 3546008..3546217 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
IT763_RS16970 3546327..3548606 - 2280 WP_016926766.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
IT763_RS16975 3548975..3549358 - 384 WP_049299550.1 DUF2570 family protein -
IT763_RS16980 3549355..3549756 - 402 WP_049299551.1 M15 family metallopeptidase -
IT763_RS16985 3549746..3550072 - 327 WP_004936551.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(27-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13163.93 Da        Isoelectric Point: 4.9139

>T181982 WP_025303801.1 NZ_CP065032:c3546011-3545655 [Serratia sp. CMO1]
MIFLTAEDIAEFNAEIVPHGRQEGSKVEAVANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRRLTE

Download         Length: 357 bp

>T181982 NZ_CP086253:3225998-3226201 [Pectobacterium aquaticum]
ATGAAAAAAATCGACTATTTGATGCGTTTGCGCAAATGCACAACTATTGACACTCTCGAACGTGTTATTGAAAAAAACAA
GTATGAACTCTCCAATGATGAACTGGAGATGTTCTTTTCCGCAGCCGATCATCGTCTGGCAGAACTGACGATGAACAAAC
TCTACGACAAAGTCCCTACAGCAGTATGGCGATACGTTCGTTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT181982 WP_004936539.1 NZ_CP065032:c3546217-3546008 [Serratia sp. CMO1]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT181982 NZ_CP086253:3225576-3225944 [Pectobacterium aquaticum]
ATGGATGAGTACACACCAAAATATTATGATATTGCCCAACTCAGATTCTTATGTGAAAATCTGTGTGACGAAAGCATAGC
AACGTTAGGCGATAGCAGTCACGGCTGGGTCAATGATCCAACATCTGCGATCAATATCCAATTAAATGAACTTATTGAGC
ATATCGCTACGTTTATTCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTTTCAGAGCAGGTTGAAAAGTATTTG
GATGATACTTACGTCTTGTTTAGCAACTATGGAATTAATGATGCTGAACTGCGACGTTGGCAGAAGTCCAAAGCAAAATT
ATTCGGAATGTTCTCAGGGGAGAACATCTGTATGCCTGCTAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References