Detailed information of TA system TA181972

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1629274..1629799
• Replicon: chromosome
• Accession: NZ_CP065032
• Organism: Serratia sp. CMO1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IT763_RS07730
• Protein ID: WP_015377296.1
• Coordinates: 1629274..1629558 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8B4GIN1
• Locus tag: IT763_RS07735
• Protein ID: WP_004928423.1
• Coordinates: 1629548..1629799 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IT763_RS07705	1624534..1625667	+	1134	WP_206195308.1	putrescine ABC transporter ATP-binding subunit PotG	-
IT763_RS07710	1625692..1626654	+	963	WP_016928361.1	putrescine ABC transporter permease PotH	-
IT763_RS07715	1626651..1627496	+	846	WP_206195309.1	putrescine ABC transporter permease PotI	-
IT763_RS07720	1627601..1628080	+	480	WP_028127974.1	YbjO family protein	-
IT763_RS07725	1628150..1629277	+	1128	WP_151254362.1	23S rRNA (uracil(747)-C(5))-methyltransferase RlmC	-
IT763_RS07730	1629274..1629558	-	285	WP_015377296.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IT763_RS07735	1629548..1629799	-	252	WP_004928423.1	prevent-host-death protein	Antitoxin
IT763_RS07740	1629901..1630635	-	735	WP_016928355.1	arginine ABC transporter substrate-binding protein	-
IT763_RS07745	1630836..1631504	-	669	WP_033637817.1	arginine ABC transporter permease ArtM	-
IT763_RS07750	1631504..1632220	-	717	WP_028127976.1	arginine ABC transporter permease ArtQ	-
IT763_RS07755	1632230..1632961	-	732	WP_004928409.1	arginine ABC transporter substrate-binding protein	-
IT763_RS07760	1632994..1633722	-	729	WP_116403778.1	arginine ABC transporter ATP-binding protein ArtP	-
IT763_RS07765	1633986..1634528	-	543	WP_206195310.1	lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10803.94 Da
• Isoelectric Point: 10.6941

>T181972 WP_015377296.1 NZ_CP065032:c1629558-1629274 [Serratia sp. CMO1]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLASVLVNPHIPANKLAGLPDCYKIKLRASGFRLVYRVMETEIVVLVLSVGK
RERSAAYTAAKKRL

Nucleotide

• Length: 285 bp

>T181972 NZ_CP086253:337478-337765 [Pectobacterium aquaticum]
ATGACCTATAAGTTAAAATTTGTGCCTTCTGCATTGAAGGAATGGAAAAAATTAGGGCACCCTGTCCGGGAGCAGTTCAA
GAAAAAGCTGGTTGAGCGTTTGGAAAATCCTCGTGTTCCTTCAGCCCAACTTCATGGCCGTAAAGACCAGTATAAAATTA
AACTGAAGTCCGCTGGCTACAGGCTGGTGTATTTGGTCCAGGATGAGACCATTACTGTGATGGTTATGGGCGTTGGAAAG
CGCGAAGGTAGCCAGATTTATTCTGATACTAAAGGTCGCTCTGCTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9108.39 Da
• Isoelectric Point: 4.5203

>AT181972 WP_004928423.1 NZ_CP065032:c1629799-1629548 [Serratia sp. CMO1]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Nucleotide

• Length: 252 bp

>AT181972 NZ_CP086253:337234-337488 [Pectobacterium aquaticum]
ATGGCTTTCAACATCCTGACTAACACAGCCGCCAGTATTACTGAGTTGAAACGTGACCCGATGGGGACGGTACGGGCTGC
TGAAGGTGAAACTATCGCTATACTGAACCGGAATGAGCCAGCGTTCTACTGTGTGCCTCCTGCCGTATTCGCTTATTTAA
TGGAACTGGCTGAAGATGCCGAACTGGGGCGTACCGTTGATGACCGGATGTCAGAACTAGCTGACGCGGAAGAGATTTCG
CCCGATGACCTATAA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GIN1