Detailed information of TA system TA181971

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1510577..1511124
• Replicon: chromosome
• Accession: NZ_CP065032
• Organism: Serratia sp. CMO1

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: A0A380ADA6
• Locus tag: IT763_RS07190
• Protein ID: WP_025302144.1
• Coordinates: 1510816..1511124 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: IT763_RS07185
• Protein ID: WP_025302143.1
• Coordinates: 1510577..1510813 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IT763_RS07170	1507063..1508598	+	1536	WP_016928459.1	glutathione ABC transporter substrate-binding protein GsiB	-
IT763_RS07175	1508651..1509571	+	921	WP_016928458.1	glutathione ABC transporter permease GsiC	-
IT763_RS07180	1509581..1510489	+	909	WP_016928457.1	glutathione ABC transporter permease GsiD	-
IT763_RS07185	1510577..1510813	+	237	WP_025302143.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
IT763_RS07190	1510816..1511124	+	309	WP_025302144.1	CcdB family protein	Toxin
IT763_RS07195	1511160..1512002	-	843	WP_015377214.1	S-formylglutathione hydrolase	-
IT763_RS07200	1512017..1513141	-	1125	WP_016928454.1	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	-
IT763_RS07205	1513172..1514092	-	921	WP_116403718.1	LysR family transcriptional regulator	-
IT763_RS07210	1514198..1515355	+	1158	WP_033640883.1	YbfB/YjiJ family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (8-78)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11504.32 Da
• Isoelectric Point: 5.0196

>T181971 WP_025302144.1 NZ_CP065032:1510816-1511124 [Serratia sp. CMO1]
MQFTVYDNTYPASAYPYLLDVQSDLIDVLSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQIGKA
VGNVNEHRNQIKAAIDFLIDGF

Nucleotide

• Length: 309 bp

>T181971 NZ_CP086253:160930-161418 [Pectobacterium aquaticum]
ATGGAGTATTTAGAAGTAAATGGTTGGAAAGTCTTCTTTCATTCATGCTTTTTGCTGCAAATAGCAGAACTTACTCAAAA
GGTTGTTGAGCTAAAGGCTGCAAAACCCGGTGAATACCTTGGCAAGAAGGAAACAAAGCTCCTACATGCGATTGAGCGTG
TGATTGAGGAATGGATAGCAGCCGATCCCCTTAACGCGCAATACCGTCAGGGAGACACTCTAGGCGATGAATTCAAACAT
TGGTTCCGCGCAAAGTTCTTGTCGCAGTTTCGTTTGTTCTATCGTTGCAGTGCGGAGCATAAGACCATCATTATCGGTTG
GGTAAATGATTTTGAGACACTTCGCGCTTACGGTTCAAAGACAGACGCCTATAAGGTGTTTTCAGGAATGTTAAAAGCGG
GCGATCCGCCAGATGACTGGGAGAAACTTCTCAGTGAGGCAAAAGCAGCCACTGCTACCTCTTCTATTTCTGGTTTCCTC
GGAAAATAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8967.04 Da
• Isoelectric Point: 5.0807

>AT181971 WP_025302143.1 NZ_CP065032:1510577-1510813 [Serratia sp. CMO1]
MANSNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Nucleotide

• Length: 237 bp

>AT181971 NZ_CP086253:160565-160906 [Pectobacterium aquaticum]
ATGACTATTCACATTAATACAGCGGACGTGTCACTGCGCGCGGAGTCTCGACTCACCGAACGCAGCCAGACAACGATTCC
GGCAGCAATACGCGATGCTTTGCATCTCAAGCCAGGTGAGTACATTAAGTACACCTTACTTGCAGGCGGCAAAGTCATCA
TGTCCCGACAGGAAGAAGAACAGGACGACCCAGTTATATCGCAGTTTCTGGCTTTTCTCGAAAACGACATGAAGAAAAAC
CCACAGAACATTTATCCCGTACCGGTAGTGTTCTGGGAAAGCATCAAAGCATTAACTGCTGGAGTTGAGGTCGATTTAGA
CGCGCCGCTTACTGATGACTAA

Structures

Toxin

• AlphaFold DB: A0A380ADA6