Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1032594..1033215 Replicon chromosome
Accession NZ_CP065032
Organism Serratia sp. CMO1

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag IT763_RS04815 Protein ID WP_004940313.1
Coordinates 1032594..1032797 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag IT763_RS04820 Protein ID WP_004940312.1
Coordinates 1032847..1033215 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT763_RS04785 1028295..1028633 + 339 WP_049299676.1 P-II family nitrogen regulator -
IT763_RS04790 1028669..1029955 + 1287 WP_206195216.1 ammonium transporter AmtB -
IT763_RS04795 1030046..1030909 - 864 WP_016928847.1 acyl-CoA thioesterase II -
IT763_RS04800 1031140..1031631 + 492 WP_016928846.1 YbaY family lipoprotein -
IT763_RS04805 1031696..1032010 - 315 WP_004940317.1 MGMT family protein -
IT763_RS04815 1032594..1032797 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
IT763_RS04820 1032847..1033215 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
IT763_RS04825 1033374..1033727 - 354 WP_016928845.1 hypothetical protein -
IT763_RS04830 1034132..1034845 + 714 WP_206195217.1 ABC transporter ATP-binding protein -
IT763_RS04835 1034842..1035699 + 858 WP_206195218.1 metal ABC transporter permease -
IT763_RS04840 1035725..1036603 + 879 WP_016928843.1 metal ABC transporter substrate-binding protein -
IT763_RS04845 1036711..1036851 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
IT763_RS04850 1036864..1037118 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T181970 WP_004940313.1 NZ_CP065032:c1032797-1032594 [Serratia sp. CMO1]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T181970 NZ_CP086253:c29219-28833 [Pectobacterium aquaticum]
ATGGAGGTTTACAGATTGGCATGGGAAATAGTCACACGGGCACTATTCGATACGTGGTTTGATGAGCAAACTGAAACGGT
ACAGGAAGAAATTTTGGCACACCTCTCTATACTCGAAGAGGATGGCCCACAGCTAGGGCGACCACAGGTTGATCAGATTA
AAGGCTCAAAATACAAAAATATGAAGGAGCTTCGAGTTCAGGTTAGCGGCAACCCATTCCGAACATTCTTCGCGTTTGAC
CGGACACGTAAAGCGATTGTTTTATGTGCAGGAGATAAGAAAGGCGAAGATGAAAAGTTGTTCTACGAACGTATGATTAA
GATCGCAGACGCTGAGTTTGCATCGCATCTGATATCACCGGAGGTAAAAGAAGATGGCGACGCTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT181970 WP_004940312.1 NZ_CP065032:c1033215-1032847 [Serratia sp. CMO1]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT181970 NZ_CP086253:c28846-28547 [Pectobacterium aquaticum]
ATGGCGACGCTTAAAGAAATGATGGCTAAACGTTCACCGGAGAGCCGCGCCCGCATTGAAGCGCGCACGGCTGAGATCCG
TCAGGAAATCACTTTAGCGAAATTACGCGAAGAGCTGAACATGTCGCAGACTCAGCTTGCGTTAGCTCTGGGCGTCAAGC
AGCCATCTATTGTTAAGATGGAGAAGGTCGAGAATGACCCAAAACTGTCAACGCTGAAACGCTATGTCACTGCCCTAGGC
GGCAAGCTTACGCTAGATGTGACCTTGCCTGATGGTAAGCGTATCGCGCTGACTTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References