Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4901633..4902168 Replicon chromosome
Accession NZ_CP065031
Organism Pectobacterium brasiliense strain F126

Toxin (Protein)


Gene name relE Uniprot ID C6DJA0
Locus tag F126LOC_RS21595 Protein ID WP_015842269.1
Coordinates 4901881..4902168 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q6DB37
Locus tag F126LOC_RS21590 Protein ID WP_010281712.1
Coordinates 4901633..4901884 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F126LOC_RS21560 4897071..4897397 + 327 WP_039510297.1 helix-turn-helix domain-containing protein -
F126LOC_RS21565 4897382..4897696 + 315 WP_039279922.1 HipA N-terminal domain-containing protein -
F126LOC_RS21570 4897693..4898733 + 1041 WP_119871557.1 HipA domain-containing protein -
F126LOC_RS21575 4898793..4899416 - 624 WP_119871556.1 LysE family translocator -
F126LOC_RS21580 4899684..4900439 + 756 WP_119871555.1 thiol:disulfide interchange protein DsbG -
F126LOC_RS21585 4900473..4901378 - 906 WP_119871554.1 siderophore-interacting protein -
F126LOC_RS21590 4901633..4901884 + 252 WP_010281712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F126LOC_RS21595 4901881..4902168 + 288 WP_015842269.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F126LOC_RS21600 4902286..4903638 - 1353 WP_119871553.1 glutathione-disulfide reductase -
F126LOC_RS21605 4903767..4904609 - 843 WP_010281707.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
F126LOC_RS21610 4904890..4905273 - 384 WP_014913665.1 TfoX/Sxy family protein -
F126LOC_RS21615 4905395..4905955 - 561 Protein_4223 alkyl/aryl-sulfatase -
F126LOC_RS21620 4906128..4906856 + 729 WP_039498362.1 DUF1266 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11074.15 Da        Isoelectric Point: 10.3527

>T181968 WP_015842269.1 NZ_CP065031:4901881-4902168 [Pectobacterium brasiliense]
MSYSVKFREDALKEWLKLDKTIQQQFAKKLKKCCENPHIPSAKLRGMKDCYKIKLRASGFRLVYEVIDDVLIIAVVAVGK
RERSGVYHLASERMR

Download         Length: 288 bp

>T181968 NZ_CP086248:6327-6584 [Clostridium sp. CF011]
ATGAATAAGATTTTTTCAGAAGTATCATGGGAGCATTATGTATATTGGCAGTCAGAGGATAAAAAAATATTAAGAAAAAT
TAATGAACTTATAAAAGACATTGAAAGAAACGGAAATGAAGGTCTAGGAAAGCCGGAAGCATTAAAGCATGAGTTGGTCG
GTTATTGGAGTCGAAGAATAACAGAAGTTCATAGACTTATATATAGTATTGATGATGAAAATATCTATGTTGCAAGCTGC
AAAGGACATTATCACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9117.47 Da        Isoelectric Point: 4.0637

>AT181968 WP_010281712.1 NZ_CP065031:4901633-4901884 [Pectobacterium brasiliense]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVDVDLD
SFL

Download         Length: 252 bp

>AT181968 NZ_CP086248:6080-6334 [Clostridium sp. CF011]
ATGATCGCTATAGGTTACTCGAATGTAAGACAGAATTTTAAAAATTATTGCGACAAAGCTACAAAAGATTTTGAAACCAT
TATTATTACTCGCGAGCGTGGTGACAACGTGGTTATGTTATCTGAATCAGCATATAATAACCTTATGGAAAATTTGTACG
TTAGAAGTGATCCCACCTATTATAATGAATTGTTGAAATCTATTGAACAATTAAAAATGGGAAAGGGAATTGAAAGGGAA
CTGCTTGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0XQ75

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2EZP0

References