Detailed information of TA system TA181961

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4184812..4185472
• Replicon: chromosome
• Accession: NZ_CP065031
• Organism: Pectobacterium brasiliense strain F126

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: F126LOC_RS18205
• Protein ID: WP_072061666.1
• Coordinates: 4184812..4185225 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A1D7Z1Z6
• Locus tag: F126LOC_RS18210
• Protein ID: WP_005971623.1
• Coordinates: 4185206..4185472 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F126LOC_RS18180	4180610..4181938	+	1329	WP_039282120.1	MHS family MFS transporter	-
F126LOC_RS18185	4182143..4182529	+	387	WP_048256533.1	acyl-CoA thioesterase	-
F126LOC_RS18190	4182872..4183390	+	519	WP_119870590.1	flavodoxin FldB	-
F126LOC_RS18195	4183419..4183742	+	324	WP_119870589.1	hypothetical protein	-
F126LOC_RS18200	4183808..4184743	-	936	WP_119870588.1	23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF	-
F126LOC_RS18205	4184812..4185225	-	414	WP_072061666.1	protein YgfX	Toxin
F126LOC_RS18210	4185206..4185472	-	267	WP_005971623.1	FAD assembly factor SdhE	Antitoxin
F126LOC_RS18215	4185708..4186709	+	1002	WP_010279836.1	tRNA-modifying protein YgfZ	-
F126LOC_RS18220	4186764..4187411	-	648	WP_010279833.1	hemolysin III family protein	-
F126LOC_RS18225	4187842..4188450	+	609	WP_010279828.1	HD domain-containing protein	-
F126LOC_RS18230	4188505..4189509	+	1005	WP_119870587.1	LacI family DNA-binding transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16325.29 Da
• Isoelectric Point: 10.7911

>T181961 WP_072061666.1 NZ_CP065031:c4185225-4184812 [Pectobacterium brasiliense]
VAQWRCDLRVSWRMQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGEIVLLSETTLNWRQQ
EWQIVKRPWLLKNGILLSLQAVNGKDKQQLWLASDSMGDDEWRHLRQILLQQKHWAR

Nucleotide

• Length: 414 bp

>T181961 NZ_CP086220:4345551-4345724 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10507.94 Da
• Isoelectric Point: 5.1392

>AT181961 WP_005971623.1 NZ_CP065031:c4185472-4185206 [Pectobacterium brasiliense]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDTDKRTFVRLLQSDDPDLFNWLMNHGEPEDGELKRMISLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT181961 NZ_CP086220:4345227-4345523 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A1D7Z1Z6