Detailed information of TA system TA181957

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 1334821..1335484
• Replicon: chromosome
• Accession: NZ_CP065031
• Organism: Pectobacterium brasiliense strain F126

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: F126LOC_RS05940
• Protein ID: WP_119870726.1
• Coordinates: 1335140..1335484 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: F126LOC_RS05935
• Protein ID: WP_119870727.1
• Coordinates: 1334821..1335138 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F126LOC_RS05915	1331358..1332935	+	1578	WP_014916196.1	glutamine-hydrolyzing GMP synthase	-
F126LOC_RS05920	1333096..1333443	-	348	WP_119870730.1	TIR domain-containing protein	-
F126LOC_RS05925	1333440..1333922	-	483	WP_119870729.1	hypothetical protein	-
F126LOC_RS05930	1334519..1334734	+	216	WP_119870728.1	helix-turn-helix domain-containing protein	-
F126LOC_RS05935	1334821..1335138	-	318	WP_119870727.1	helix-turn-helix domain-containing protein	Antitoxin
F126LOC_RS05940	1335140..1335484	-	345	WP_119870726.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F126LOC_RS05945	1335709..1336737	-	1029	WP_119870725.1	helix-turn-helix domain-containing protein	-
F126LOC_RS05950	1336905..1337678	+	774	WP_119870724.1	alpha/beta hydrolase	-
F126LOC_RS05955	1337714..1338334	+	621	WP_119870723.1	FMN-dependent NADH-azoreductase	-
F126LOC_RS05960	1338374..1338682	+	309	WP_014916188.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-86)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 12393.08 Da
• Isoelectric Point: 9.7825

>T181957 WP_119870726.1 NZ_CP065031:c1335484-1335140 [Pectobacterium brasiliense]
MKSLYWVGSSKKDLQSLPADVQDVFGYALHVAQTGGKHTQAKPLKGFGGAGVLEVVEDYIGDTYRAVYTVKFGEAVYVLH
TFQKKSSSGIATPKSDMNTIRERLKTAENHAKGA

Nucleotide

• Length: 345 bp

>T181957 NZ_CP086220:c3152226-3151843 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11419.48 Da
• Isoelectric Point: 10.6133

>AT181957 WP_119870727.1 NZ_CP065031:c1335138-1334821 [Pectobacterium brasiliense]
MSLDIEVSSGNVYADLGNVHAEDMLVKAQLATLISSIIKSRRLTQAEAAKLLGMPQPKLSNLLRGQFRGISETKMLECLT
KLGRDIQIVVGKPRRTPGSVKVVFA

Nucleotide

• Length: 318 bp

>AT181957 NZ_CP086220:c3152684-3152316 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA