Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 183633..184250 Replicon chromosome
Accession NZ_CP065031
Organism Pectobacterium brasiliense strain F126

Toxin (Protein)


Gene name hicA Uniprot ID C6DHN3
Locus tag F126LOC_RS00810 Protein ID WP_010281507.1
Coordinates 184071..184250 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A086ESS8
Locus tag F126LOC_RS00805 Protein ID WP_014916995.1
Coordinates 183633..184043 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F126LOC_RS00790 179497..180540 - 1044 WP_010281514.1 DNA-binding transcriptional regulator CytR -
F126LOC_RS00795 180849..183047 - 2199 WP_104209601.1 primosomal protein N' -
F126LOC_RS00800 183321..183536 + 216 WP_010281510.1 50S ribosomal protein L31 -
F126LOC_RS00805 183633..184043 - 411 WP_014916995.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F126LOC_RS00810 184071..184250 - 180 WP_010281507.1 type II toxin-antitoxin system HicA family toxin Toxin
F126LOC_RS00815 184334..185344 - 1011 WP_119870817.1 iron ABC transporter permease -
F126LOC_RS00820 185341..186303 - 963 WP_014916993.1 ABC transporter substrate-binding protein -
F126LOC_RS00825 186313..187110 - 798 WP_119870818.1 ABC transporter ATP-binding protein -
F126LOC_RS00830 187344..187661 - 318 WP_005973355.1 met regulon transcriptional regulator MetJ -
F126LOC_RS00835 187849..189009 + 1161 WP_039465321.1 cystathionine gamma-synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6560.69 Da        Isoelectric Point: 10.7838

>T181955 WP_010281507.1 NZ_CP065031:c184250-184071 [Pectobacterium brasiliense]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T181955 NZ_CP086220:c2905193-2904786 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14506.39 Da        Isoelectric Point: 4.3391

>AT181955 WP_014916995.1 NZ_CP065031:c184043-183633 [Pectobacterium brasiliense]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLIEMGQDIPTVSSVGQLAKSAEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR

Download         Length: 411 bp

>AT181955 NZ_CP086220:c2905440-2905174 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2I1S0

Antitoxin

Source ID Structure
AlphaFold DB A0A086ESS8

References