Detailed information of TA system TA181950

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 4049458..4050008
• Replicon: chromosome
• Accession: NZ_CP065030
• Organism: Pectobacterium versatile strain F131

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: F131LOC_RS18030
• Protein ID: WP_103861886.1
• Coordinates: 4049700..4050008 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: F131LOC_RS18025
• Protein ID: WP_103861885.1
• Coordinates: 4049458..4049697 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F131LOC_RS18005	4044928..4045239	-	312	WP_103861881.1	AzlD domain-containing protein	-
F131LOC_RS18010	4045236..4045970	-	735	WP_103942238.1	AzlC family ABC transporter permease	-
F131LOC_RS18015	4046076..4046912	-	837	WP_103971080.1	AraC family transcriptional regulator	-
F131LOC_RS18020	4047134..4048753	-	1620	WP_103971081.1	Tar ligand binding domain-containing protein	-
F131LOC_RS18025	4049458..4049697	+	240	WP_103861885.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
F131LOC_RS18030	4049700..4050008	+	309	WP_103861886.1	CcdB family protein	Toxin
F131LOC_RS18035	4050149..4050313	-	165	WP_039483441.1	glucose uptake inhibitor SgrT	-
F131LOC_RS18040	4050404..4052062	+	1659	WP_103971082.1	HTH-type transcriptional regulator SgrR	-
F131LOC_RS18045	4052280..4053260	+	981	WP_145963920.1	thiamine ABC transporter substrate binding subunit	-
F131LOC_RS18050	4053236..4054843	+	1608	WP_103971083.1	thiamine/thiamine pyrophosphate ABC transporter permease ThiP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (9-79)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11799.66 Da
• Isoelectric Point: 9.3363

>T181950 WP_103861886.1 NZ_CP065030:4049700-4050008 [Pectobacterium versatile]
MQYKVYRNNGNSNSYPYLLNIQSDIIGELHTRLVIPLFPLHKIARPPARRLTPIVTIEGNDYLIMTHEMASVRRSQLGHE
VMDAQVYRKTIKDAVDFLLDGF

Nucleotide

• Length: 309 bp

>T181950 NZ_CP086220:1936663-1937037 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9036.37 Da
• Isoelectric Point: 10.0137

>AT181950 WP_103861885.1 NZ_CP065030:4049458-4049697 [Pectobacterium versatile]
MPLTSVRHKKTVSVTLEPVLLQQAREAGINLSAILTEALKREIRLSEGEKWKQQNQKALQELNRITDKHGLLSDDDRTF

Nucleotide

• Length: 240 bp

>AT181950 NZ_CP086220:1936206-1936574 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA