Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4049458..4050008 Replicon chromosome
Accession NZ_CP065030
Organism Pectobacterium versatile strain F131

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag F131LOC_RS18030 Protein ID WP_103861886.1
Coordinates 4049700..4050008 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag F131LOC_RS18025 Protein ID WP_103861885.1
Coordinates 4049458..4049697 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F131LOC_RS18005 4044928..4045239 - 312 WP_103861881.1 AzlD domain-containing protein -
F131LOC_RS18010 4045236..4045970 - 735 WP_103942238.1 AzlC family ABC transporter permease -
F131LOC_RS18015 4046076..4046912 - 837 WP_103971080.1 AraC family transcriptional regulator -
F131LOC_RS18020 4047134..4048753 - 1620 WP_103971081.1 Tar ligand binding domain-containing protein -
F131LOC_RS18025 4049458..4049697 + 240 WP_103861885.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
F131LOC_RS18030 4049700..4050008 + 309 WP_103861886.1 CcdB family protein Toxin
F131LOC_RS18035 4050149..4050313 - 165 WP_039483441.1 glucose uptake inhibitor SgrT -
F131LOC_RS18040 4050404..4052062 + 1659 WP_103971082.1 HTH-type transcriptional regulator SgrR -
F131LOC_RS18045 4052280..4053260 + 981 WP_145963920.1 thiamine ABC transporter substrate binding subunit -
F131LOC_RS18050 4053236..4054843 + 1608 WP_103971083.1 thiamine/thiamine pyrophosphate ABC transporter permease ThiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11799.66 Da        Isoelectric Point: 9.3363

>T181950 WP_103861886.1 NZ_CP065030:4049700-4050008 [Pectobacterium versatile]
MQYKVYRNNGNSNSYPYLLNIQSDIIGELHTRLVIPLFPLHKIARPPARRLTPIVTIEGNDYLIMTHEMASVRRSQLGHE
VMDAQVYRKTIKDAVDFLLDGF

Download         Length: 309 bp

>T181950 NZ_CP086220:1936663-1937037 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9036.37 Da        Isoelectric Point: 10.0137

>AT181950 WP_103861885.1 NZ_CP065030:4049458-4049697 [Pectobacterium versatile]
MPLTSVRHKKTVSVTLEPVLLQQAREAGINLSAILTEALKREIRLSEGEKWKQQNQKALQELNRITDKHGLLSDDDRTF

Download         Length: 240 bp

>AT181950 NZ_CP086220:1936206-1936574 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References