Detailed information of TA system TA181949

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 3378115..3378778
• Replicon: chromosome
• Accession: NZ_CP065030
• Organism: Pectobacterium versatile strain F131

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: F131LOC_RS15030
• Protein ID: WP_103971625.1
• Coordinates: 3378115..3378459 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: F131LOC_RS15035
• Protein ID: WP_039538898.1
• Coordinates: 3378461..3378778 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F131LOC_RS15005	3373671..3374801	+	1131	WP_103971620.1	linear amide C-N hydrolase	-
F131LOC_RS15010	3374911..3375219	-	309	WP_103971621.1	hypothetical protein	-
F131LOC_RS15015	3375259..3375879	-	621	WP_103971622.1	FMN-dependent NADH-azoreductase	-
F131LOC_RS15020	3375914..3376687	-	774	WP_103971623.1	alpha/beta hydrolase	-
F131LOC_RS15025	3376855..3377883	+	1029	WP_103971624.1	helix-turn-helix domain-containing protein	-
F131LOC_RS15030	3378115..3378459	+	345	WP_103971625.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F131LOC_RS15035	3378461..3378778	+	318	WP_039538898.1	helix-turn-helix domain-containing protein	Antitoxin
F131LOC_RS15040	3378993..3379208	-	216	WP_010279992.1	helix-turn-helix domain-containing protein	-
F131LOC_RS15045	3379315..3379545	+	231	WP_040032477.1	helix-turn-helix domain-containing protein	-
F131LOC_RS15050	3379628..3379846	+	219	WP_103971631.1	helix-turn-helix domain-containing protein	-
F131LOC_RS15055	3379912..3380768	+	857	Protein_2949	hypothetical protein	-
F131LOC_RS15060	3380957..3381283	+	327	WP_164500089.1	type II toxin-antitoxin system RelE/ParE family toxin	-
F131LOC_RS15065	3381288..3381626	+	339	WP_010279998.1	putative addiction module antidote protein	-
F131LOC_RS15070	3381729..3382331	-	603	WP_103941405.1	TetR/AcrR family transcriptional regulator	-
F131LOC_RS15075	3382449..3383372	+	924	WP_103940837.1	NADP-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-86)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 12446.15 Da
• Isoelectric Point: 9.7991

>T181949 WP_103971625.1 NZ_CP065030:3378115-3378459 [Pectobacterium versatile]
MKSLYWVGSSKKDLQSLPADVQDVFGYALHLAQTGGKHTQAKPLKGFGGAGVLEVVEDYIGDTYRAVYTVRFGEAVYVLH
AFQKKSSSGIATQKPDMNTIRERLKTAENHAKGA

Nucleotide

• Length: 345 bp

>T181949 NZ_CP086220:c1690712-1690609 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11448.48 Da
• Isoelectric Point: 10.6133

>AT181949 WP_039538898.1 NZ_CP065030:3378461-3378778 [Pectobacterium versatile]
MSQDIEVSSGNVYADLGNLHAEDMLVKAQLATLISSIIKSRRLTQAEAAKLLGMPQPKLSNLLRGQFRGISETKMLECLT
KLGRDIQIVVGKPRRTPGSVKVVFA

Nucleotide

• Length: 318 bp

>AT181949 NZ_CP086220:1690571-1690842 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT