Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1221614..1222250 Replicon chromosome
Accession NZ_CP065030
Organism Pectobacterium versatile strain F131

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag F131LOC_RS05450 Protein ID WP_103941744.1
Coordinates 1221614..1221796 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag F131LOC_RS05455 Protein ID WP_103970630.1
Coordinates 1221819..1222250 (+) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F131LOC_RS05425 1216979..1217182 + 204 WP_005976130.1 YbdD/YjiX family protein -
F131LOC_RS05430 1217199..1218185 + 987 WP_103970626.1 GTPase -
F131LOC_RS05435 1218454..1219836 + 1383 WP_103970627.1 glycoside hydrolase family 28 protein -
F131LOC_RS05440 1220070..1220549 - 480 WP_103970628.1 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK -
F131LOC_RS05445 1220620..1221438 - 819 WP_103970629.1 TraB/GumN family protein -
F131LOC_RS05450 1221614..1221796 + 183 WP_103941744.1 type II toxin-antitoxin system HicA family toxin Toxin
F131LOC_RS05455 1221819..1222250 + 432 WP_103970630.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F131LOC_RS05460 1222344..1225067 - 2724 WP_103970631.1 copper-exporting P-type ATPase CopA -
F131LOC_RS05465 1225183..1225590 + 408 WP_103970632.1 Cu(I)-responsive transcriptional regulator -
F131LOC_RS05470 1225626..1226081 - 456 WP_103970633.1 NfeD family protein -
F131LOC_RS05475 1226081..1226995 - 915 WP_010301277.1 SPFH/Band 7/PHB domain protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-138)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6512.68 Da        Isoelectric Point: 10.3299

>T181944 WP_103941744.1 NZ_CP065030:1221614-1221796 [Pectobacterium versatile]
MTSTDLIKELAAAGCECKRHNGGSHQIWWSPITGKTFPVPHPKKDLPLGTVKSIKKMAGI

Download         Length: 183 bp

>T181944 NZ_CP086220:c1011104-1010997 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 16036.95 Da        Isoelectric Point: 4.3145

>AT181944 WP_103970630.1 NZ_CP065030:1221819-1222250 [Pectobacterium versatile]
MFFSVGVETPKDDATAYGLIVPALCTDDYGCFSAADSQQEIARMAREAILTIIDEAVSRGNLDIKRLNDAGHLIYAAIPD
FADYDSWFVLDVDLSAFEGKPQRLNISLPDTLIQRIDNRVREQPGTYRDRSHFLAEAARHELE

Download         Length: 432 bp

>AT181944 NZ_CP086220:1011157-1011218 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References