Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 390515..391107 Replicon chromosome
Accession NZ_CP065030
Organism Pectobacterium versatile strain F131

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag F131LOC_RS01725 Protein ID WP_103971367.1
Coordinates 390515..390769 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag F131LOC_RS01730 Protein ID WP_095701362.1
Coordinates 390766..391107 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F131LOC_RS01710 386542..386730 + 189 WP_039470389.1 hypothetical protein -
F131LOC_RS01715 386900..387451 + 552 WP_103971365.1 polymer-forming cytoskeletal protein -
F131LOC_RS01720 387483..390203 + 2721 WP_103971366.1 CRISPR-associated helicase/endonuclease Cas3 -
F131LOC_RS01725 390515..390769 + 255 WP_103971367.1 type II toxin-antitoxin system HicA family toxin Toxin
F131LOC_RS01730 390766..391107 + 342 WP_095701362.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F131LOC_RS01735 391738..393306 + 1569 WP_103971368.1 type I-E CRISPR-associated protein Cse1/CasA -
F131LOC_RS01740 393290..393937 + 648 WP_010308671.1 type I-E CRISPR-associated protein Cse2/CasB -
F131LOC_RS01745 393941..395008 + 1068 WP_103971369.1 type I-E CRISPR-associated protein Cas7/Cse4/CasC -
F131LOC_RS01750 395018..395752 + 735 WP_103971370.1 type I-E CRISPR-associated protein Cas5/CasD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(55-100)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9612.09 Da        Isoelectric Point: 11.2749

>T181938 WP_103971367.1 NZ_CP065030:390515-390769 [Pectobacterium versatile]
MNKRHQRTLSDLFSRPVNSSIKWSDIESLFIALGAEIHEREGSRIAVLLKGEKKIFHRPHPRPTTDKGAVNSIRVWLESL
GVRP

Download         Length: 255 bp

>T181938 NZ_CP086215:2713701-2713805 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12384.98 Da        Isoelectric Point: 4.4547

>AT181938 WP_095701362.1 NZ_CP065030:390766-391107 [Pectobacterium versatile]
MINTLLIDGHTAVIAFDSEIEMFRGEFIGLNGGADFYAYSVDELKKEGATSLAIFLDECRRDGIEPYKSYSGKVTTRLTP
ERHAALAVTAQATGVSINELLNEGVDLVLERRS

Download         Length: 342 bp

>AT181938 NZ_CP086215:c2713963-2713800 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References