Detailed information of TA system TA181937

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-DnaT
• Location: 338012..338543
• Replicon: chromosome
• Accession: NZ_CP065030
• Organism: Pectobacterium versatile strain F131

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: F131LOC_RS01490
• Protein ID: WP_103861633.1
• Coordinates: 338256..338543 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: A0A3R8PFZ6
• Locus tag: F131LOC_RS01485
• Protein ID: WP_039470361.1
• Coordinates: 338012..338266 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F131LOC_RS01460	333344..333934	-	591	WP_005975525.1	DnaA initiator-associating protein DiaA	-
F131LOC_RS01465	334123..334479	-	357	WP_039279491.1	YraN family protein	-
F131LOC_RS01470	334476..336494	-	2019	WP_103971348.1	penicillin-binding protein activator	-
F131LOC_RS01475	336556..337443	+	888	WP_103861634.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-
F131LOC_RS01485	338012..338266	+	255	WP_039470361.1	plasmid stabilization protein	Antitoxin
F131LOC_RS01490	338256..338543	+	288	WP_103861633.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F131LOC_RS01495	338719..339504	+	786	WP_103971349.1	4,5-DOPA dioxygenase extradiol	-
F131LOC_RS01500	339691..340851	-	1161	WP_010297418.1	glutathionylspermidine synthase family protein	-
F131LOC_RS01505	340862..341536	-	675	WP_103861630.1	DUF1190 family protein	-
F131LOC_RS01510	341802..343196	-	1395	WP_103971350.1	outer membrane channel protein TolC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10994.91 Da
• Isoelectric Point: 10.6699

>T181937 WP_103861633.1 NZ_CP065030:338256-338543 [Pectobacterium versatile]
MTYKLKFVPSALKEWKKLGHPVREQFKKKLVERLEDPRVPSAQLHGRKDQYKIKLKSAGYRLVYLVQDETITVMVMGVGK
REGSQIYSDTKGRSA

Nucleotide

• Length: 288 bp

>T181937 NZ_CP086215:2452508-2452774 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9192.34 Da
• Isoelectric Point: 3.7947

>AT181937 WP_039470361.1 NZ_CP065030:338012-338266 [Pectobacterium versatile]
MAFNILTNTAASITELKRDPMGTVRAAEGETIAILNRNEPAFYCVPPAVFAYLMELAEDAELGRTVDDRMSELADAEEIS
PDDL

Nucleotide

• Length: 255 bp

>AT181937 NZ_CP086215:2452257-2452508 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A3R8PFZ6