181936

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 126978..127612 Replicon chromosome
Accession NZ_CP065030
Organism Pectobacterium versatile strain F131

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag F131LOC_RS00530 Protein ID WP_103971408.1
Coordinates 126978..127253 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A221T3Z5
Locus tag F131LOC_RS00535 Protein ID WP_010308714.1
Coordinates 127250..127612 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F131LOC_RS00515 123967..125337 - 1371 WP_103862317.1 envelope stress sensor histidine kinase CpxA -
F131LOC_RS00520 125334..126032 - 699 WP_010308725.1 envelope stress response regulator transcription factor CpxR -
F131LOC_RS00525 126186..126710 + 525 WP_103971410.1 cell-envelope stress modulator CpxP -
F131LOC_RS00530 126978..127253 + 276 WP_103971408.1 type II toxin-antitoxin system HicA family toxin Toxin
F131LOC_RS00535 127250..127612 + 363 WP_010308714.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F131LOC_RS00540 127874..131617 + 3744 WP_196387953.1 DUF4132 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-85)

Antitoxin

Uncharacterised protein family HicB

(61-113)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10020.63 Da        Isoelectric Point: 11.1875

>T181936 WP_103971408.1 NZ_CP065030:126978-127253 [Pectobacterium versatile]
MQGKIASLRKKQRETLSHIFKTPILSGVKWSSIESLVTALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVSL
REWLESIGVKP

Download         Length: 276 bp

>T181936 NZ_CP086215:2427050-2427157 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13495.29 Da        Isoelectric Point: 4.6225

>AT181936 WP_010308714.1 NZ_CP065030:127250-127612 [Pectobacterium versatile]
MTKALNTPNTMVVSGQPAIISYVPEIGMFRGKFIGLSGYCDFVADSINGLRSEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERHISVNTFIVETLSEHLKQA

Download         Length: 363 bp

>AT181936 NZ_CP086215:c2427234-2427174 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A221T3Z5

References