Detailed information of TA system TA181935

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 110184..110889
• Replicon: chromosome
• Accession: NZ_CP065030
• Organism: Pectobacterium versatile strain F131

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: F131LOC_RS00440
• Protein ID: WP_103971416.1
• Coordinates: 110464..110889 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: F131LOC_RS00435
• Protein ID: WP_103943792.1
• Coordinates: 110184..110483 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F131LOC_RS00410	105405..106187	-	783	WP_103862325.1	hydroxypyruvate isomerase family protein	-
F131LOC_RS00415	106221..106877	-	657	WP_103862324.1	aldolase	-
F131LOC_RS00420	106874..108148	-	1275	WP_103971418.1	four-carbon acid sugar kinase family protein	-
F131LOC_RS00425	108145..109059	-	915	WP_103971417.1	NAD(P)-dependent oxidoreductase	-
F131LOC_RS00430	109398..110159	+	762	WP_103862321.1	DeoR/GlpR family DNA-binding transcription regulator	-
F131LOC_RS00435	110184..110483	-	300	WP_103943792.1	helix-turn-helix domain-containing protein	Antitoxin
F131LOC_RS00440	110464..110889	-	426	WP_103971416.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F131LOC_RS00445	111387..112082	+	696	WP_103971415.1	hypothetical protein	-
F131LOC_RS00450	112084..112500	+	417	WP_103971450.1	hypothetical protein	-
F131LOC_RS00455	112611..112889	+	279	Protein_90	DUF1778 domain-containing protein	-
F131LOC_RS00460	112880..113359	+	480	Protein_91	GNAT family N-acetyltransferase	-
F131LOC_RS00465	113492..114826	+	1335	WP_010303220.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
F131LOC_RS00470	114899..115786	+	888	WP_103157850.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (3-123)

Antitoxin

• Cro/C1-type helix-turn-helix domain (46-86)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15583.05 Da
• Isoelectric Point: 8.8228

>T181935 WP_103971416.1 NZ_CP065030:c110889-110464 [Pectobacterium versatile]
VAVYTTKLFDKKLKSEILSDCYLCEIAHEVMNGRFEGDFGGGVIKKRIALNAGKSAGARTIIFFKLGSNLFFADGWKKNQ
VRKGVKEIQDDELAVYKDIAGDLLQLTVQQIAQLVKVKELREVECDGCKDERAAGNGKKPA

Nucleotide

• Length: 426 bp

>T181935 NZ_CP086215:2395766-2396032 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11209.74 Da
• Isoelectric Point: 10.0902

>AT181935 WP_103943792.1 NZ_CP065030:c110483-110184 [Pectobacterium versatile]
MAKSLHEHGGITDTTMERINNRVAAREFRERIEQAHAMSGAEIQNMRSRYKMSQSSLAYALNMSVESVSKWERNEKKPSG
AALRLLNIINEKGLDIFAS

Nucleotide

• Length: 300 bp

>AT181935 NZ_CP086215:2395509-2395766 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA