Detailed information of TA system TA181934

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): spoIISABC/SpoIISA-SpoIISB
• Location: 1379487..1380406
• Replicon: chromosome
• Accession: NZ_CP065029
• Organism: Bacillus licheniformis strain LCDD6

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: ICC24_RS06955
• Protein ID: WP_073425551.1
• Coordinates: 1379660..1380406 (-)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: spoIISB
• Uniprot ID: T5HT37
• Locus tag: ICC24_RS06950
• Protein ID: WP_003180877.1
• Coordinates: 1379487..1379660 (-)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICC24_RS06930	1374912..1376009	+	1098	WP_003180867.1	mannonate dehydratase	-
ICC24_RS06935	1375985..1376833	+	849	WP_009328728.1	SDR family oxidoreductase	-
ICC24_RS06940	1376860..1377873	+	1014	WP_003180872.1	zinc-binding alcohol dehydrogenase family protein	-
ICC24_RS06945	1377926..1379197	+	1272	WP_011197811.1	MFS transporter	-
ICC24_RS06950	1379487..1379660	-	174	WP_003180877.1	type II toxin-antitoxin system SpoIISB family antitoxin	Antitoxin
ICC24_RS06955	1379660..1380406	-	747	WP_073425551.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
ICC24_RS06960	1380517..1381515	-	999	WP_009328723.1	inorganic phosphate transporter	-
ICC24_RS06965	1381528..1382145	-	618	WP_003180884.1	DUF47 domain-containing protein	-
ICC24_RS06970	1382478..1384235	+	1758	WP_017474396.1	gamma-glutamyltransferase	-
ICC24_RS06975	1384364..1385008	+	645	WP_009328721.1	YesL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (3-238)

Antitoxin

• Antitoxin SpoIISB (1-57)

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 29447.86 Da
• Isoelectric Point: 4.5367

>T181934 WP_073425551.1 NZ_CP065029:c1380406-1379660 [Bacillus licheniformis]
MLLFYQFLVWLIVLALALYVAAVWRFEKQLTEKTVPIRKTWYLLYVIGAVIYWTHDPQSIFTNPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSSELATDTRMLLEENNDLLHTYQNRLKTFQYLLKNEPIHIYYGNIEAYAEGIEKLIKRFAEKMNISAAL
CEYNSEESKDHLLEHMENRFDVQEKLDRKDVYYEENGKMVLIPFSIHDFDYVMKLTSEDLVTEFDYLLFTSLTSIYDLLL
PNEEEGDD

Nucleotide

• Length: 747 bp

>T181934 NZ_CP086215:1249708-1249896 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6945.04 Da
• Isoelectric Point: 10.9186

>AT181934 WP_003180877.1 NZ_CP065029:c1379660-1379487 [Bacillus licheniformis]
MEPAFQQDQESVKKRLAFKMFKRQSKTNIAKYEVSPHTERIFRQNERLIGEYKRKKA

Nucleotide

• Length: 174 bp

>AT181934 NZ_CP086215:1249419-1249679 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Antitoxin

• AlphaFold DB: T5HT37