Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 556318..556954 Replicon chromosome
Accession NZ_CP065029
Organism Bacillus licheniformis strain LCDD6

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag ICC24_RS02755 Protein ID WP_003179128.1
Coordinates 556604..556954 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag ICC24_RS02750 Protein ID WP_006638778.1
Coordinates 556318..556599 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICC24_RS02730 551433..552914 + 1482 WP_009330132.1 PH domain-containing protein -
ICC24_RS02735 552911..553510 - 600 WP_003179118.1 rhomboid family intramembrane serine protease -
ICC24_RS02740 553853..554812 + 960 WP_152847888.1 outer membrane lipoprotein carrier protein LolA -
ICC24_RS02745 555037..556206 + 1170 WP_026080763.1 alanine racemase -
ICC24_RS02750 556318..556599 + 282 WP_006638778.1 hypothetical protein Antitoxin
ICC24_RS02755 556604..556954 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
ICC24_RS02760 557072..557899 + 828 WP_061578564.1 RsbT co-antagonist protein RsbRA -
ICC24_RS02765 557903..558268 + 366 WP_003179132.1 STAS domain-containing protein -
ICC24_RS02770 558271..558672 + 402 WP_003179135.1 anti-sigma regulatory factor -
ICC24_RS02775 558683..559690 + 1008 WP_003179137.1 PP2C family protein-serine/threonine phosphatase -
ICC24_RS02780 559749..560075 + 327 WP_003179140.1 anti-sigma factor antagonist -
ICC24_RS02785 560075..560560 + 486 WP_003179142.1 anti-sigma B factor RsbW -
ICC24_RS02790 560526..561317 + 792 WP_003179144.1 RNA polymerase sigma factor SigB -
ICC24_RS02795 561314..561913 + 600 WP_003179145.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T181933 WP_003179128.1 NZ_CP065029:556604-556954 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T181933 NZ_CP086215:c173381-173286 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT181933 WP_006638778.1 NZ_CP065029:556318-556599 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT181933 NZ_CP086215:173201-173258 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References