Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1740279..1740934 Replicon chromosome
Accession NZ_CP065027
Organism Actinomyces sp. zg-993

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I2V18_RS07645 Protein ID WP_196716697.1
Coordinates 1740279..1740698 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I2V18_RS07650 Protein ID WP_196716698.1
Coordinates 1740695..1740934 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I2V18_RS07630 1735681..1737378 + 1698 WP_194949271.1 phosphoenolpyruvate--protein phosphotransferase -
I2V18_RS07635 1737375..1738331 + 957 WP_196716696.1 thioesterase family protein -
I2V18_RS07640 1738461..1740143 + 1683 WP_194949267.1 energy-dependent translational throttle protein EttA -
I2V18_RS07645 1740279..1740698 - 420 WP_196716697.1 type II toxin-antitoxin system VapC family toxin Toxin
I2V18_RS07650 1740695..1740934 - 240 WP_196716698.1 antitoxin Antitoxin
I2V18_RS07655 1741039..1742160 - 1122 WP_196716699.1 peptide chain release factor 2 -
I2V18_RS07660 1742315..1743997 - 1683 WP_196716700.1 phospho-sugar mutase -
I2V18_RS07665 1743999..1744652 - 654 WP_196716701.1 deoxyribose-phosphate aldolase -
I2V18_RS07670 1744682..1745389 - 708 WP_194949261.1 purine-nucleoside phosphorylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15496.72 Da        Isoelectric Point: 5.2046

>T181932 WP_196716697.1 NZ_CP065027:c1740698-1740279 [Actinomyces sp. zg-993]
VIILDTNVISEPLRRSPDPAVARWLDDQAQSSLYLTALTVAELCTGVEMLPGGRRRDNLRQRLESDVFPFFADRVLPFDL
AAAQAWAEIQTEARRRGRPLPVMDSLIASIARVHGFALATRNIKDLESTGVTLINPWTD

Download         Length: 420 bp

>T181932 NZ_CP086215:121720-121872 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8665.78 Da        Isoelectric Point: 5.7012

>AT181932 WP_196716698.1 NZ_CP065027:c1740934-1740695 [Actinomyces sp. zg-993]
MPSMVIRNLPERTHQALKARARRHGRSTEAEARAVLGEAVAEEAGQRLGSILTSIRQEVGELDLDGIRDAAPYEPMDLS

Download         Length: 240 bp

>AT181932 NZ_CP086215:121096-121695 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References