Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1246271..1246869 Replicon plasmid pSymA
Accession NZ_CP065021
Organism Sinorhizobium meliloti strain S35m

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag I0J99_RS23215 Protein ID WP_013845238.1
Coordinates 1246271..1246564 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag I0J99_RS23220 Protein ID WP_014989717.1
Coordinates 1246561..1246869 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I0J99_RS23200 1242191..1243393 + 1203 WP_010967204.1 IS256-like element ISRm3 family transposase -
I0J99_RS23205 1243644..1244416 - 773 Protein_1200 ParB N-terminal domain-containing protein -
I0J99_RS23210 1244810..1246009 + 1200 WP_164828738.1 NAD-dependent formate dehydrogenase -
I0J99_RS23215 1246271..1246564 - 294 WP_013845238.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
I0J99_RS23220 1246561..1246869 - 309 WP_014989717.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I0J99_RS23225 1247086..1247988 - 903 Protein_1204 ParB N-terminal domain-containing protein -
I0J99_RS23230 1248345..1248701 + 357 WP_017269414.1 type II toxin-antitoxin system RelE/ParE family toxin -
I0J99_RS23235 1248691..1249014 + 324 WP_003526806.1 DNA-binding transcriptional regulator -
I0J99_RS23240 1249205..1250731 - 1527 WP_107608023.1 amidohydrolase -
I0J99_RS23245 1250728..1251666 - 939 WP_014989524.1 nucleoside hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..1514798 1514798
- flank IS/Tn - - 1242191..1243393 1202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-53)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11202.84 Da        Isoelectric Point: 6.4735

>T181926 WP_013845238.1 NZ_CP065021:c1246564-1246271 [Sinorhizobium meliloti]
MRLVWARYALDDRDTIFSSIERENPRAAVHVDEEIVSAVRRLLDFPESGRPGRIAGTRELVIPRTPYIAAYMVMEDRIRI
LRVLHGAQKWPSELDDG

Download         Length: 294 bp

>T181926 NZ_CP086213:2833567-2833848 [Pseudomonas aeruginosa]
ATGACCTATGAGCTGGAGTTCCTGCCCTCAGCCCTGAAGGAGTGGCAGAAGCTCGGCCATACGGTGCGCGAGCAGATCAA
AAAGAAACTGCGCGAGCGCCTGGATAATCCCAAGGTTCAGGCCGACGCCCTCAGGGATATGCCGGGGCACTACAAAATCA
AGCTGCGTGCATCGGGCTATCGTCTGGTATACCGCGTCGAAGATGAGCGCGTGGTGGTCGTGGTGGTTGCCGTTGGCAAG
CGCGAGCGTGGGGCCGCTTACCAATCTGCCAAGGGCCGTTAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11228.61 Da        Isoelectric Point: 5.6604

>AT181926 WP_014989717.1 NZ_CP065021:c1246869-1246561 [Sinorhizobium meliloti]
MASNALVQTRIDAEVKERATAVLENMGLTVSDAVRILLTRTANEGALPLELFSHSEAHDAWFRAKVLRALEDTRPDVDDA
DADAHFRERRAAAMRKAAAGDR

Download         Length: 309 bp

>AT181926 NZ_CP086213:2833332-2833577 [Pseudomonas aeruginosa]
ATGCAGAGTATCTTGGCTGACGTCGCTGTCAGCGTTTCTGAGTTGAAGAAAAATCCGTCGGGCATCCTGGCTGGTGCAGG
TGGTATGCCTGTCGCCGTGCTCAACCACAATCGCGTCATGGGATACATGGTGCCGGCAGAGCTCTATGAGCAGATGATGG
AGCGCCTAGATGATCTGGAGTTGGTCGAAATAGTGAAGGCTCGCTCGGGCGAGGAGTCTGTCCCGGTGCGTTTGGATGAC
CTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References