Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 2644503..2645176 Replicon chromosome
Accession NZ_CP065020
Organism Sinorhizobium meliloti strain S35m

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I0J99_RS12780 Protein ID WP_107608227.1
Coordinates 2644772..2645176 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I0J99_RS12775 Protein ID WP_107608226.1
Coordinates 2644503..2644775 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I0J99_RS12755 2640493..2642133 - 1641 WP_003536336.1 ABC transporter substrate-binding protein -
I0J99_RS12760 2642181..2643236 - 1056 WP_014529838.1 dipeptidase -
I0J99_RS12765 2643416..2643757 - 342 WP_003536339.1 EamA family transporter -
I0J99_RS12770 2643806..2644366 - 561 WP_107608225.1 TetR/AcrR family transcriptional regulator -
I0J99_RS12775 2644503..2644775 + 273 WP_107608226.1 antitoxin Antitoxin
I0J99_RS12780 2644772..2645176 + 405 WP_107608227.1 type II toxin-antitoxin system VapC family toxin Toxin
I0J99_RS12785 2645304..2645696 + 393 WP_107608228.1 globin -
I0J99_RS12790 2645702..2646076 + 375 WP_107608229.1 DUF423 domain-containing protein -
I0J99_RS12795 2646199..2646459 + 261 WP_107608230.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
I0J99_RS12800 2646574..2646888 - 315 WP_003536354.1 antibiotic biosynthesis monooxygenase -
I0J99_RS12805 2646901..2647167 - 267 WP_107608231.1 hypothetical protein -
I0J99_RS12810 2647220..2647633 - 414 WP_003536357.1 DUF2325 domain-containing protein -
I0J99_RS12815 2647841..2648767 - 927 WP_010969930.1 energy transducer TonB -
I0J99_RS12820 2648808..2649242 - 435 WP_027990618.1 hypothetical protein -
I0J99_RS12825 2649472..2649612 + 141 WP_027990619.1 hemin uptake protein HemP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(16-55)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14747.98 Da        Isoelectric Point: 5.1974

>T181919 WP_107608227.1 NZ_CP065020:2644772-2645176 [Sinorhizobium meliloti]
MNGYLLDTNIISDIIHNPFGPAAQRIERIGPKEIYTSIVVASELRYGCAKKGSAKLLAKVESLLEIVPVLPLDIPADTRY
GSIRAELESLGQTIGSNDLLIAAHAYGLDLTLVTDNIREFSRVRGLSLENWLER

Download         Length: 405 bp

>T181919 NZ_CP086206:c1655757-1655443 [Pseudomonas sp. HN8-3]
ATGATTTTCATAGAGACGTCAGTCTTCACCCGTCGCGTTAAAGAATTGATCGACGAGGATGCCTACACGGCTCTTCAGAA
CGTGTTGGTAGTCAACCCTTCTGCTGGCGATGTAATCGAGGGTACGGGTGGAGTTCGCAAGATACGAGTAGCAGCCAAGG
GCCATGGCAAACGAGGCGGGGCGCGGGTGATCTATTACCACTTCGTCTCGGCATCACAGATTGTTCTACTGATGATCTAT
CCCAAAAATGAACAGCAGGACTTGACTGCCGACGAGCGCAAGTCACTGAAGGCTGCGATTGAGCACTGGAGATAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10348.01 Da        Isoelectric Point: 6.3951

>AT181919 WP_107608226.1 NZ_CP065020:2644503-2644775 [Sinorhizobium meliloti]
MPVPLPSSRPREVKLFRNNRSQAVRIPAEFELPGDRVLIRREGTRLIIEPVARPADIVELLAEWKKEAPLGPEDRFPDVE
DIPARPEKIF

Download         Length: 273 bp

>AT181919 NZ_CP086206:c1655440-1655153 [Pseudomonas sp. HN8-3]
ATGAGCAGATTTTTTGATGAATTGATGGAAAGCGTTCAAGAGATGAACGAGATCCTGCGCGGAGAACGCGAACCTTCTCG
TGAATTCCATGTTGATTCAATGCGAGTCAAAGAGATCCGTAAGGCGACAGGGCTGACCCAGGCTAAATTCGCAGCGCTGA
TTGATGTGCAACTTGGCACATTACGTAACTGGGAGCAGGGTCGTCGTGAACCTACCGGACCAGCAAAGGCATTGTTGAAA
GCTATCCATAATGACCCAGTCCATGTACTGAATGCGTTGGCTAGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References