Detailed information of TA system TA181915

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 858505..859145
• Replicon: chromosome
• Accession: NZ_CP065020
• Organism: Sinorhizobium meliloti strain S35m

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: H0G6N1
• Locus tag: I0J99_RS04015
• Protein ID: WP_003533691.1
• Coordinates: 858505..858891 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: H0G6N0
• Locus tag: I0J99_RS04020
• Protein ID: WP_003533689.1
• Coordinates: 858891..859145 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I0J99_RS03990	853969..854448	+	480	WP_003537307.1	GNAT family N-acetyltransferase	-
I0J99_RS03995	854492..854941	-	450	WP_003537305.1	nucleoside deaminase	-
I0J99_RS04000	855016..856737	+	1722	WP_010968830.1	pseudouridine synthase	-
I0J99_RS04005	856744..857304	+	561	WP_010968831.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
I0J99_RS04010	857377..858276	+	900	WP_010968832.1	patatin-like phospholipase family protein	-
I0J99_RS04015	858505..858891	-	387	WP_003533691.1	type II toxin-antitoxin system VapC family toxin	Toxin
I0J99_RS04020	858891..859145	-	255	WP_003533689.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
I0J99_RS04025	859284..861116	-	1833	WP_010968833.1	monovalent cation:proton antiporter-2 (CPA2) family protein	-
I0J99_RS04030	861268..862614	+	1347	WP_010968834.1	TldD/PmbA family protein	-
I0J99_RS04035	862723..863541	+	819	WP_010968835.1	3'(2'),5'-bisphosphate nucleotidase CysQ	-
I0J99_RS04040	863602..863838	+	237	WP_003533684.1	DUF4170 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-83)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 13904.77 Da
• Isoelectric Point: 4.5716

>T181915 WP_003533691.1 NZ_CP065020:c858891-858505 [Sinorhizobium meliloti]
MVIDTSAIAAIAFNEQEAGSFREKIADDPVRLISAATALEAAMVIETRLGEAAGAELDLWLYKANVEIVAVTAEHMDQAR
RAWRRFGKGRHPAGLNFGDCFSYALAFLTNEPLLFKGSDFSQTDIPAA

Nucleotide

• Length: 387 bp

>T181915 NZ_CP086203:c2532598-2532245 [Morganella morganii]
GTGTGGAAGATAGTCACAACAGATAATTTTACAGCGTGGTTTGCTGAGCAGGATGACGGAGATCGCGCAGCAATACTGGC
AGCGATGCTGGTATTGGAGAAGCGGGGACCCGGCTTACCAAGGCCGTATGCGGATACTGTAAAAGGTTCCCGGTATACGA
ATATGAAAGAGCTTCGTATACAGAGCAGGGGACAACCGATACGGGCATTTTTTGCATTCGCCCCTGAGAGAAGAGGCGTC
TTGCTGTGTGCGGGGTATAAAACCGGCAAAGAAAAACGTTTTTATATGCAGATGATCCCGCAGGCTGACCGTGAGTATAC
AGAATGGCTGAACAGGCCGGAAAACAGGAGTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9472.63 Da
• Isoelectric Point: 4.8660

>AT181915 WP_003533689.1 NZ_CP065020:c859145-858891 [Sinorhizobium meliloti]
MALSIKDTETEQLARTLARRTGESITLATKRALEERLRRTDTAARRAALLEDLEAIQRRWNAMPVLDSRSSDDIIGYDED
GLPS

Nucleotide

• Length: 255 bp

>AT181915 NZ_CP086203:c2532242-2531940 [Morganella morganii]
ATGGGAAAGTCACTCAGACAACTGCTGGCTGAGGAAAAGCCGGAAGTCGCAGCGGCTGCACGGGTTCAGGCAGATGAGAT
CCTGCTGAATATCCATCTGGCGGAGTTGCGGGAGAAAGTGAAGAAAACACAGGTGGAAATGGCGCAGGCATTGGGAATAA
AACAGCCGACAGTCGCCGGGATGGAAAAACCGGGGCATGATGTCAAGTTATCCACGCTGAGACGCTATGTGGATGCCATC
GGCGGAAAACTGAATATTGATGTTGAACTACCGGACGGCACGCATTATATGTTCCGGGTCTGA

Structures

Toxin

• AlphaFold DB: H0G6N1

Antitoxin

• AlphaFold DB: H0G6N0