Detailed information of TA system TA181912

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-YefM
• Location: 2321833..2322348
• Replicon: chromosome
• Accession: NZ_CP064954
• Organism: Corynebacterium lizhenjunii strain ZJ-599

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: G7Y31_RS10660
• Protein ID: WP_165007379.1
• Coordinates: 2322094..2322348 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: G7Y31_RS10655
• Protein ID: WP_165007376.1
• Coordinates: 2321833..2322093 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7Y31_RS10640	2317339..2318592	+	1254	WP_165007370.1	HNH endonuclease	-
G7Y31_RS10645	2318803..2319969	-	1167	WP_165007492.1	FUSC family protein	-
G7Y31_RS10650	2320351..2321385	-	1035	WP_165007373.1	class II fructose-bisphosphate aldolase	-
G7Y31_RS10655	2321833..2322093	+	261	WP_165007376.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
G7Y31_RS10660	2322094..2322348	+	255	WP_165007379.1	Txe/YoeB family addiction module toxin	Toxin
G7Y31_RS10665	2322628..2323824	-	1197	WP_165007382.1	glycoside hydrolase family 76	-
G7Y31_RS10670	2323903..2324520	-	618	WP_165007495.1	RNA methyltransferase	-
G7Y31_RS10675	2324771..2325325	-	555	WP_165007385.1	orotate phosphoribosyltransferase	-
G7Y31_RS10680	2325445..2326299	-	855	WP_165007497.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-66)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10003.44 Da
• Isoelectric Point: 9.6753

>T181912 WP_165007379.1 NZ_CP064954:2322094-2322348 [Corynebacterium lizhenjunii]
VRLVWDESAWEDYKYWQTADRKVLKRINSLIDACMRDPFSGIGKPKQLKYGAQGSWSRRITTEHRLVYLVNGEDLVILQA
RYHY

Nucleotide

• Length: 255 bp

>T181912 NZ_CP086202:c124093-123608 [Enterobacter roggenkampii]
GTGGGACGTGTAACAGCTCCGGAACCGTTATCCAGCTCACATCAACTGGCTGAGTTCGTAAGCGGGGAGGCCGTTCTCGA
TCACTGGCTTAAACAGCGAGGGTTAAAAAATCAGGCTCTTGGTGCTGCCCGGACATTCATTGTATGTAAAACAGGCACCA
AACAGGTTGCCGGTTTTTACTCCCTGGCCACCGGCAGCGTTAACCATGTTGAAGCGACGGGAAGTCTCAGGCGCAATATG
CCAGATCCAATCCCGGTTATCATACTTGCTCGCCTGGCTGTCGGTGTCTCACTTCGTGGACAAGGGCTGGGTGCTGATTT
ACTGCACGATGCAGTATTGCGCTGCTATCGTGTAGCTGGAAATATTGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAACTTTTATCTTCACCATGGCTTTAAGGCATCGAAAACTCAGGAACGGACATTATTTTTAAAGTTACCA
CAGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9796.94 Da
• Isoelectric Point: 4.8181

>AT181912 WP_165007376.1 NZ_CP064954:2321833-2322093 [Corynebacterium lizhenjunii]
MSISASQARKTLYPLIERVNEDQDAIEIVSRKGNVVLMPADEYAAWQETAYLFRSPTNARRLLDAYDRALAGKTHVHELD
RSDEDC

Nucleotide

• Length: 261 bp

>AT181912 NZ_CP086202:c124368-124081 [Enterobacter roggenkampii]
TTGCTATACAAGGGGGCACTAATGAAATCAGAAGTTCAACTCAATCTCAGAGCCAAAGAATCTCAAAGAGCACTCATCGA
TGCTGCTGCAGAGATACTTCATAAATCACGTACGGATTTCATTCTGGAAATGGCATGCCAGGCTGCGGAGAATGTGATCC
TTGATCGACGTGTATTTAATTTTAACGATGAGCAGTATGCCGAGTTTATCGATATGCTCGATGCGCCAGTTGCGGATGAC
GCTGCCATCAATAAACTCCTGGCAAGGAAACCTCAGTGGGACGTGTAA