Detailed information of TA system TA181911

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1516946..1517607
• Replicon: chromosome
• Accession: NZ_CP064952
• Organism: Schaalia sp. ZJ405

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G7Y41_RS06265
• Protein ID: WP_165215831.1
• Coordinates: 1516946..1517371 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G7Y41_RS06270
• Protein ID: WP_165215834.1
• Coordinates: 1517368..1517607 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G7Y41_RS06240	1512242..1513717	-	1476	WP_165217636.1	ABC transporter ATP-binding protein	-
G7Y41_RS06245	1513732..1514412	-	681	WP_165215823.1	energy-coupling factor transporter transmembrane protein EcfT	-
G7Y41_RS06250	1514445..1515065	-	621	WP_196819472.1	MptD family putative ECF transporter S component	-
G7Y41_RS06255	1515645..1516418	-	774	WP_165316307.1	DNA alkylation repair protein	-
G7Y41_RS06260	1516478..1516855	-	378	WP_196819473.1	hypothetical protein	-
G7Y41_RS06265	1516946..1517371	-	426	WP_165215831.1	type II toxin-antitoxin system VapC family toxin	Toxin
G7Y41_RS06270	1517368..1517607	-	240	WP_165215834.1	Arc family DNA-binding protein	Antitoxin
G7Y41_RS06275	1518097..1519034	+	938	Protein_1210	DNA polymerase III subunit epsilon	-
G7Y41_RS06280	1519327..1519836	+	510	WP_165215839.1	ClbS/DfsB family four-helix bundle protein	-
G7Y41_RS06285	1519973..1520563	-	591	WP_165215841.1	hypothetical protein	-
G7Y41_RS06290	1521201..1522187	+	987	WP_165316306.1	metal ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1506513..1520563	14050

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

• Arc-like DNA binding domain (17-43)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15727.98 Da
• Isoelectric Point: 6.7204

>T181911 WP_165215831.1 NZ_CP064952:c1517371-1516946 [Schaalia sp. ZJ405]
MIVLDTNVLSEPLRRDSDPAVARWLDAQHPLTLYVTTLTVAELRAGVEALPEGHRRDLLRKRVEDELIPFFADRILPFDN
PASRAWARLQANAHSQGRPLPAMDSLIAAIASSRRYALATCNTADFSTTGIELINPWRVIS

Nucleotide

• Length: 426 bp

>T181911 NZ_CP086202:c23387-22971 [Enterobacter roggenkampii]
GTGAACAAAATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGGGGTCACCGCATTGTGGTTTCGGCCATTACCTACGCCGAGATGCGCTTCGGCGCCACCGGGC
CGAAGGCCGCGCCGCGTCACGTCCAGCTGGTTGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGCATGGCCGGCACGCCGATTGGCCCGAACGACACGGCGATTGC
CGGACACGCCATCGCCGCCGGCGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTGCCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8725.78 Da
• Isoelectric Point: 6.4813

>AT181911 WP_165215834.1 NZ_CP064952:c1517607-1517368 [Schaalia sp. ZJ405]
MASVIVRNLSESTHRALKARAHEHGRSMEAEIRTILNETVAREPHRGLGALLTSIRQEAGGFDVDVTRDSSIYEPVDLS

Nucleotide

• Length: 240 bp

>AT181911 NZ_CP086202:c23614-23384 [Enterobacter roggenkampii]
ATGCGCACAGTCTCTATTTTTAAAAACGGCAACAACCGCGCCATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGGGTTAACCTGTGA