Detailed information of TA system TA181910

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 267954..268670
• Replicon: chromosome
• Accession: NZ_CP064946
• Organism: Pseudomonas fulva strain ZDHY414

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: IZU98_RS01125
• Protein ID: WP_196110298.1
• Coordinates: 268488..268670 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0S4I868
• Locus tag: IZU98_RS01120
• Protein ID: WP_049696767.1
• Coordinates: 267954..268400 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IZU98_RS01105	265150..265356	-	207	WP_023535792.1	DUF3079 domain-containing protein	-
IZU98_RS01110	265694..266506	+	813	WP_059183457.1	alpha/beta hydrolase	-
IZU98_RS01115	266499..267656	+	1158	WP_049696768.1	HAMP domain-containing histidine kinase	-
IZU98_RS01120	267954..268400	-	447	WP_049696767.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IZU98_RS01125	268488..268670	-	183	WP_196110298.1	type II toxin-antitoxin system HicA family toxin	Toxin
IZU98_RS01130	270048..272096	-	2049	WP_196110299.1	RNA-directed DNA polymerase	-
IZU98_RS01135	272089..273435	-	1347	WP_196110300.1	RNA-directed DNA polymerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6843.83 Da
• Isoelectric Point: 11.4650

>T181910 WP_196110298.1 NZ_CP064946:c268670-268488 [Pseudomonas fulva]
VHSRDIIKRLKDDGWVRVKGTDGSHQQFKHPTKKGRVTVPHPNKDVATGTLRNIWKQAGF

Nucleotide

• Length: 183 bp

>T181910 NZ_CP086201:c3860279-3859869 [Enterobacter roggenkampii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGCTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGCGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAATGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16381.38 Da
• Isoelectric Point: 4.3924

>AT181910 WP_049696767.1 NZ_CP064946:c268400-267954 [Pseudomonas fulva]
MKYPVVLHKDEDSDYGVTVPDVPGCFSAGETIDEALSEVQLALEMHFEGLVEDGEPLPQPQNIEIHRKDPAYADGIWAFV
EFDVTPYYGKSVRFNASLPEGLLKRIDDRVKEDSAYASRSGFLAAAALHELAKNLNEGIDALKTRKTV

Nucleotide

• Length: 447 bp

>AT181910 NZ_CP086201:c3860526-3860260 [Enterobacter roggenkampii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACACCTTAAGCGACGACGATAAGCGTCTGTTTGTCCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0S4I868