Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4243..4829 Replicon plasmid pVIM-1-ZDHY316
Accession NZ_CP064944
Organism Pseudomonas fulva strain ZDHY316

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag IYR97_RS22915 Protein ID WP_150345860.1
Coordinates 4530..4829 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag IYR97_RS22910 Protein ID WP_196113758.1
Coordinates 4243..4533 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IYR97_RS22885 1..1248 + 1248 WP_196113754.1 replication initiation protein -
IYR97_RS22890 1527..1850 + 324 WP_182275391.1 hypothetical protein -
IYR97_RS22895 1847..2653 + 807 WP_196113755.1 ParA family protein -
IYR97_RS22900 2646..3710 + 1065 WP_196113756.1 ParB/RepB/Spo0J family partition protein -
IYR97_RS22905 3697..3960 + 264 WP_196113757.1 hypothetical protein -
IYR97_RS22910 4243..4533 - 291 WP_196113758.1 putative addiction module antidote protein Antitoxin
IYR97_RS22915 4530..4829 - 300 WP_150345860.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IYR97_RS22920 4968..5270 + 303 WP_196113759.1 hypothetical protein -
IYR97_RS22925 5285..5770 - 486 WP_196113760.1 hypothetical protein -
IYR97_RS22930 5857..6570 - 714 WP_196113761.1 SprT-like domain-containing protein -
IYR97_RS22935 7040..7597 + 558 WP_196113762.1 plasmid mobilization relaxosome protein MobC -
IYR97_RS22940 7584..8615 + 1032 WP_196113763.1 type IV secretion system protein VirD2 -
IYR97_RS22945 8692..8943 + 252 WP_196113764.1 hypothetical protein -
IYR97_RS22950 8930..9268 + 339 WP_196113765.1 hypothetical protein -
IYR97_RS22955 9258..9608 + 351 WP_196113766.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaVIM-1 - 1..50708 50708


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-91)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11135.79 Da        Isoelectric Point: 10.2244

>T181908 WP_150345860.1 NZ_CP064944:c4829-4530 [Pseudomonas fulva]
MIEIKQTATFMTWESKLKDQRAKAAIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQTRDIETAKRLANEWRPQ

Download         Length: 300 bp

>T181908 NZ_CP086201:c2833927-2833824 [Enterobacter roggenkampii]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10299.84 Da        Isoelectric Point: 4.7527

>AT181908 WP_196113758.1 NZ_CP064944:c4533-4243 [Pseudomonas fulva]
MTEPIYDYDPAQALDGPEAIAVFIADALDTGDAAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLV
VMRALGVDLTARPHAQ

Download         Length: 291 bp

>AT181908 NZ_CP086201:2833817-2833962 [Enterobacter roggenkampii]
AATAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References