Detailed information of TA system TA181907

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 276101..276817
• Replicon: chromosome
• Accession: NZ_CP064943
• Organism: Pseudomonas fulva strain ZDHY316

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: IYR97_RS01155
• Protein ID: WP_196110298.1
• Coordinates: 276635..276817 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0S4I868
• Locus tag: IYR97_RS01150
• Protein ID: WP_049696767.1
• Coordinates: 276101..276547 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IYR97_RS01130	271185..273224	+	2040	Protein_215	TonB-dependent siderophore receptor	-
IYR97_RS01135	273297..273503	-	207	WP_023535792.1	DUF3079 domain-containing protein	-
IYR97_RS01140	273841..274653	+	813	WP_059183457.1	alpha/beta hydrolase	-
IYR97_RS01145	274646..275803	+	1158	WP_049696768.1	HAMP domain-containing histidine kinase	-
IYR97_RS01150	276101..276547	-	447	WP_049696767.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IYR97_RS01155	276635..276817	-	183	WP_196110298.1	type II toxin-antitoxin system HicA family toxin	Toxin
IYR97_RS01160	278195..280243	-	2049	WP_196110299.1	RNA-directed DNA polymerase	-
IYR97_RS01165	280236..281582	-	1347	WP_196110300.1	RNA-directed DNA polymerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	265644..283043	17399

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6843.83 Da
• Isoelectric Point: 11.4650

>T181907 WP_196110298.1 NZ_CP064943:c276817-276635 [Pseudomonas fulva]
VHSRDIIKRLKDDGWVRVKGTDGSHQQFKHPTKKGRVTVPHPNKDVATGTLRNIWKQAGF

Nucleotide

• Length: 183 bp

>T181907 NZ_CP086201:1663850-1664371 [Enterobacter roggenkampii]
GTGGACAATCTCACGATCGAAATGTTTTCAGAGGGAAAAGACTATGATTTCAGGGACTTCGATTGTGGTGAACCCTCGCT
AAATGTCTTCCTCACAGAACATCTGGTGCGTCAGCACAATGGGCGTATTTTACGAGGCTATTTGCTTAAAGATCGCGATG
GTCCGCGAGTCCTGGGCTATTACACGTTGTCTGGTAGTTGCTTTGAAAAAGCGATGCTGCCTTCTAAGACTCAGCAGCGT
CGGATCCCTTATAGCAACGTACCGAGCGTAACGCTGGGACGTCTGGCGATACATAAAGACTTACAGGGGCTGGAGTGGGG
AACGACGCTCGTCACGCATGCCATGCGGGTTGTCTATCTGGCATCGCAGGCGGTGGGCGTACACGGAATATTTGTTGATG
CACTCAACGACCAGGCAAAACAATTTTATCTGAAGCAGGGCTTTATTCCGCTGACGGATGAAAACAGCCATTCTCTTTTC
TTTCCTACAAAATCTATCGAACGACTGTTTGAGCAGGCGTGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16381.38 Da
• Isoelectric Point: 4.3924

>AT181907 WP_049696767.1 NZ_CP064943:c276547-276101 [Pseudomonas fulva]
MKYPVVLHKDEDSDYGVTVPDVPGCFSAGETIDEALSEVQLALEMHFEGLVEDGEPLPQPQNIEIHRKDPAYADGIWAFV
EFDVTPYYGKSVRFNASLPEGLLKRIDDRVKEDSAYASRSGFLAAAALHELAKNLNEGIDALKTRKTV

Nucleotide

• Length: 447 bp

>AT181907 NZ_CP086201:1663574-1663843 [Enterobacter roggenkampii]
ATGCCAGCACTGAAAAAACAGCGTATCGATCTTCGCTTAACGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACGAATCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGGGCAGCGGAAGTCATCGAGCAGCACCGCCGTC
TCGTATTAAACGAAGCATCCTGGAATGCGGTGATGGATGCCATCGACAATCCACCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCAAAACGTCTTCGAAACATGGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0S4I868