Detailed information of TA system TA181903

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 844676..845274
• Replicon: plasmid pBS3d
• Accession: NZ_CP064935
• Organism: Rhizobium phaseoli strain BS3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HER27_RS31375
• Protein ID: WP_081279432.1
• Coordinates: 844676..844969 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7X6J1Z1
• Locus tag: HER27_RS31380
• Protein ID: WP_064820408.1
• Coordinates: 844966..845274 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HER27_RS31350	839992..840753	-	762	WP_064820405.1	SDR family oxidoreductase	-
HER27_RS31355	840893..841756	+	864	WP_037144412.1	LysR family transcriptional regulator	-
HER27_RS31360	841767..842186	-	420	Protein_777	error-prone DNA polymerase	-
HER27_RS31365	843489..843791	-	303	WP_185185227.1	diguanylate cyclase	-
HER27_RS31370	843788..844162	-	375	WP_185185226.1	hypothetical protein	-
HER27_RS31375	844676..844969	-	294	WP_081279432.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HER27_RS31380	844966..845274	-	309	WP_064820408.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HER27_RS31385	845590..846378	-	789	WP_081279433.1	NAD(P)-dependent alcohol dehydrogenase	-
HER27_RS31390	846563..846946	-	384	WP_064820409.1	DoxX family protein	-
HER27_RS31395	846961..847809	-	849	WP_064820410.1	SDR family oxidoreductase	-
HER27_RS31400	847945..848346	+	402	WP_064820580.1	helix-turn-helix transcriptional regulator	-
HER27_RS31410	848387..848834	-	448	Protein_786	transposase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	gmd	1..1111454	1111454
	-	flank	IS/Tn	-	-	848491..848703	212

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-53)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10624.19 Da
• Isoelectric Point: 5.7996

>T181903 WP_081279432.1 NZ_CP064935:c844969-844676 [Rhizobium phaseoli]
VKLTWSVFALSDRDAIFTYIEAENPSAAILVDERIVAAVRRLIDFPASGRVGRIAGTRELVINGTPYVAAYAITETAVRI
LRVLHGAQEWPDTLPTS

Nucleotide

• Length: 294 bp

>T181903 NZ_CP086201:150978-151163 [Enterobacter roggenkampii]
GTGAAAAGTGCGGATGTCATTACTGTTCTGATCAGCCATGGCTGGAAATGTGTCAGAACGAAAGGAAGCCATCATCAGTT
TCGCCATCCCGAACAGAAAGGGCTGGTTACTGTCCCACATCCCAAGAAGGATATTAAACCGGGCACTCTCGCCCAGATCT
GGCGACAGGCGGGTATTAAACACTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11013.38 Da
• Isoelectric Point: 6.4721

>AT181903 WP_064820408.1 NZ_CP064935:c845274-844966 [Rhizobium phaseoli]
MAANALVQTRIDAEVRDRASAVLENMGLTVSDAVRILLTRTANEGALPLELLSGSEAHDAWFRTKVLEALNDTRPDVSDN
EAEAHFAARRAAARLKAGSRKS

Nucleotide

• Length: 309 bp

>AT181903 NZ_CP086201:151178-151585 [Enterobacter roggenkampii]
ATGTTTTATCCGGCTTACATTCATTCTGACTCCGACGGTAGCGCCAGCGGCTTTTTCCCTGACGTTCCAGGCTGTTTTTT
TGCAGGTGATTCCCTGGACGACGCTTTTCAGGATGCGCGTGATGCGCTCACAGCACACTTCGAAGCGCTATTTGAAATGG
ATAATGCACTGCCACTTCCGGGTAATGTGGAAGCGCATCTGGAAAGTCGTCCTGAGGATTTCACTGGCGGGCAATGGCTG
TTGGTAGATATTAATATGAAACAGTTCGACGGTAGGGCCGAGCGTATCAACATCACGATGCCTCGACGTTTGCTGGTAAA
AATTGATTCCTTTGTCAGCGAGCATCCTCAGTTCGGTAATCGAAGCGCATTTCTGGCTGAGGCAGCACGTCGCGTGCTGC
CTGGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A7X6J1Z1