Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 2878088..2878749 Replicon chromosome
Accession NZ_CP064931
Organism Rhizobium phaseoli strain BS3

Toxin (Protein)


Gene name vapB Uniprot ID B3PTF5
Locus tag HER27_RS13760 Protein ID WP_010025678.1
Coordinates 2878342..2878749 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B3PTF6
Locus tag HER27_RS13755 Protein ID WP_004676069.1
Coordinates 2878088..2878342 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HER27_RS13730 2873913..2874377 - 465 WP_012483093.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
HER27_RS13735 2874396..2874635 - 240 WP_012483092.1 hypothetical protein -
HER27_RS13740 2874866..2875531 + 666 WP_064825820.1 glutathione S-transferase family protein -
HER27_RS13745 2875638..2876534 - 897 WP_004676067.1 LysR family transcriptional regulator -
HER27_RS13750 2877007..2877984 + 978 WP_064824980.1 phosphodiester glycosidase family protein -
HER27_RS13755 2878088..2878342 + 255 WP_004676069.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HER27_RS13760 2878342..2878749 + 408 WP_010025678.1 type II toxin-antitoxin system VapC family toxin Toxin
HER27_RS13765 2878795..2879415 - 621 WP_012483086.1 glutathione S-transferase -
HER27_RS13770 2879665..2880021 - 357 WP_010007611.1 hypothetical protein -
HER27_RS13775 2880163..2880918 + 756 WP_041683574.1 DeoR/GlpR family DNA-binding transcription regulator -
HER27_RS13780 2880919..2881926 - 1008 WP_012483085.1 asparaginase -
HER27_RS13785 2882416..2883627 + 1212 WP_012483084.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-62)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14756.97 Da        Isoelectric Point: 6.9902

>T181895 WP_010025678.1 NZ_CP064931:2878342-2878749 [Rhizobium phaseoli]
MYLVDTNIVSEARRGTPQAVTWLRSVDPLSIHLSALTLGEIMRGIALKQKSDPKAAGHLAEWLRKLRHDHGARILPVTDQ
IAVEWGRIAAIRPRGDIDGLIAATAIVHDLIVVTRNVGDFNDTGVSVIDPWEPSA

Download         Length: 408 bp

>T181895 NZ_CP086198:c1284621-1284409 [Macrococcus canis]
ATGTACAAAATTGTAATGAAATCTAGTGTTAAGAAAGATTTAAAGAAGATAAAAAACACGCACTTTCTAAAAATCATTAA
ACTGCTTAATGAAAATCCATATAATAATAACCATTCTTTCGAAAAACTAATTTCTCCAATAAAGGGGTTTAATTCGAGAA
GGATAAATGTACAACATCGTGTTGTTTATTCGGCGTATGGACATTATGAGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9325.40 Da        Isoelectric Point: 4.7730

>AT181895 WP_004676069.1 NZ_CP064931:2878088-2878342 [Rhizobium phaseoli]
MEWQLQDAKNQFSKVVQRARDEGPQVVTLRGERTAVVLSARDYDALRAGRPTLVDDLLGGPAWDDELADAVEARAKNPSR
SVTF

Download         Length: 255 bp

>AT181895 NZ_CP086198:c1284872-1284621 [Macrococcus canis]
ATGAATACTTATACACCTGCTAATGCTAGAAAAGATTTTTTCAACATTATCAAATCTGTTAATGAAGATAGTAAAGAAAT
ATATATCGCACCAACTAAAATTGGAGAAAAAGGTGCTGTTTTAGTCGGTGAAGATGATTGGAATGCTATTCAGGAAACTT
TATTCTTATTAGAAAAAGGTATCGCTTATCAAATTGAACAACGTAAAGACGAAGAAGAAATTGATTTTGACAGTACTTGG
GATAATATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A192T5A8

Antitoxin

Source ID Structure
AlphaFold DB A0A2U3D218

References