Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 5629314..5629891 Replicon chromosome
Accession NZ_CP064923
Organism Acaryochloris marina S15

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag I1H34_RS25700 Protein ID WP_212663681.1
Coordinates 5629314..5629643 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID -
Locus tag I1H34_RS25705 Protein ID WP_212663682.1
Coordinates 5629631..5629891 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I1H34_RS25670 (I1H34_25630) 5624937..5625164 + 228 WP_212663676.1 hypothetical protein -
I1H34_RS25675 (I1H34_25635) 5625261..5625524 - 264 WP_212663677.1 Mo-dependent nitrogenase C-terminal domain-containing protein -
I1H34_RS25680 (I1H34_25640) 5626002..5627411 + 1410 WP_212663678.1 chloride channel protein -
I1H34_RS25685 (I1H34_25645) 5627563..5627766 + 204 WP_212663679.1 hypothetical protein -
I1H34_RS25690 (I1H34_25650) 5627790..5628479 + 690 WP_249369636.1 HAD family hydrolase -
I1H34_RS25695 (I1H34_25655) 5628534..5628995 - 462 WP_212663680.1 hypothetical protein -
I1H34_RS25700 (I1H34_25660) 5629314..5629643 - 330 WP_212663681.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I1H34_RS25705 (I1H34_25665) 5629631..5629891 - 261 WP_212663682.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I1H34_RS25710 (I1H34_25670) 5630011..5631219 - 1209 WP_212663683.1 HEAT repeat domain-containing protein -
I1H34_RS25715 (I1H34_25675) 5631463..5632962 + 1500 Protein_4926 ferredoxin--nitrite reductase -
I1H34_RS32340 5632987..5633379 + 393 WP_249370223.1 2Fe-2S iron-sulfur cluster binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12440.65 Da        Isoelectric Point: 9.1414

>T181892 WP_212663681.1 NZ_CP064923:c5629643-5629314 [Acaryochloris marina S15]
MGVVVKRFDVFLVNLDPTVESEIQKTRPCIVISPNEMNQYIATVIIAPMTTKGRQYPTRVACQFQGKDGQIVLDKIRTVD
KKRLVKKLGQINQDEQQMLLSILTEMFAE

Download         Length: 330 bp

>T181892 NZ_CP086198:439986-440336 [Macrococcus canis]
ATGAAACGTGGAGATGTTTATTTAGCTGATCTGTCACCAGTGAAGGGGTCTGAACAAGGCGGTAAACGCCCCGTCGTTAT
TATTCAGAATAATATTGGGAATAAACATAGTCCTACAGTGATTGTAGCCGCAATTACAGCAAAGATTAATAAGGCAAAGA
TCCCCACCCATGTGGAAATTGGCAAGACCACGCATCACCTGGAAAAGGATTCGGTAATATTGCTTGAACAAATTAGAACT
ATTGATAAGAATAGGTTAATTGATCATCTGACAGTGCTTGATAAGGCAAAGATGAAAGAAGTGGATGTGGCACTTTTAAT
TAGTTTAGGGTTATCAATCGATAGTGAATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9692.76 Da        Isoelectric Point: 4.1228

>AT181892 WP_212663682.1 NZ_CP064923:c5629891-5629631 [Acaryochloris marina S15]
MDTAIRTRIVKIGNSQGIRIPKLLLEQSGLNGEVEITVQGDCLTIRTAECSRAGWDAAFASMAQHHDDVFLDEVNTTDWD
DTEWEW

Download         Length: 261 bp

>AT181892 NZ_CP086198:439845-439985 [Macrococcus canis]
ATGAGCCAGAAGCTGGAGCAAATGCTGATAGAAGGATATCAATCAATGGCAGAGATTAATTTATCGATAGCATCAGAACA
TTATATATTAGAATGTGAAGTTAATGATAACCATCAGACATATACCCTTGATGGTGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References