Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2584875..2585467 Replicon chromosome
Accession NZ_CP064923
Organism Acaryochloris marina S15

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag I1H34_RS12365 Protein ID WP_212665883.1
Coordinates 2584875..2585129 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag I1H34_RS12370 Protein ID WP_212665884.1
Coordinates 2585126..2585467 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I1H34_RS12325 (I1H34_12320) 2580475..2580879 - 405 Protein_2295 reverse transcriptase/maturase family protein -
I1H34_RS32155 2580946..2581499 + 554 Protein_2296 IS1 family transposase -
I1H34_RS12340 (I1H34_12335) 2581551..2582261 - 711 WP_212665847.1 IS6 family transposase -
I1H34_RS12345 (I1H34_12340) 2582372..2582599 - 228 WP_212665879.1 hypothetical protein -
I1H34_RS12350 (I1H34_12345) 2582975..2583634 + 660 WP_212665880.1 Uma2 family endonuclease -
I1H34_RS12355 (I1H34_12350) 2583639..2584166 + 528 WP_212665881.1 hypothetical protein -
I1H34_RS12360 (I1H34_12355) 2584150..2584806 + 657 WP_212665882.1 hypothetical protein -
I1H34_RS12365 (I1H34_12360) 2584875..2585129 + 255 WP_212665883.1 type II toxin-antitoxin system HicA family toxin Toxin
I1H34_RS12370 (I1H34_12365) 2585126..2585467 + 342 WP_212665884.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I1H34_RS12375 (I1H34_12370) 2585726..2586316 + 591 WP_212665885.1 hypothetical protein -
I1H34_RS12380 (I1H34_12375) 2586343..2587039 + 697 Protein_2305 IS630 family transposase -
I1H34_RS12385 (I1H34_12380) 2587061..2587567 - 507 WP_212665886.1 transposase -
I1H34_RS12390 (I1H34_12385) 2587606..2588124 - 519 WP_212662770.1 winged helix-turn-helix domain-containing protein -
I1H34_RS12395 (I1H34_12390) 2588164..2588766 - 603 Protein_2308 IS4 family transposase -
I1H34_RS12400 (I1H34_12395) 2588801..2590153 - 1353 WP_212665839.1 ISKra4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 2574622..2597255 22633


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-80)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9959.73 Da        Isoelectric Point: 10.5399

>T181885 WP_212665883.1 NZ_CP064923:2584875-2585129 [Acaryochloris marina S15]
MTRKEKLIKRFLTRPKDFTWDELVVLLAFFQFSEVSTGKTGGSRRRFINEEGLVISLHKPHPRKILKKYQIEQVMDILEQ
EGLL

Download         Length: 255 bp

>T181885 NZ_CP086196:c3833133-3832804 [Xanthomonas oryzae]
TTGCATCATGTCGCCGAACGCCGATGGCCGTTTCTGTTTACTGACAGCCACGCCTACTGCCAGTTGGCGAGCTTCTATTC
CGATTTATCTGATCTCGACAAGATCGACTGGCCGTTGCTCCAAGCACGCGATTTCCGGCGCGACCCAGACGACCCAGCCA
AGTTCGAGCGCTATCAGGCCGAGGCCCTGATTCACCGACACTTGCCGCTTGATGGCCTGCGCGGCATTGTGTGTCATACG
GATGGTTTGAAACAGACCATCGAGCGGCAACTCCAAGAGCGAAACCTGAAATTGCCGGTTCATACCCGCACCGATTGGTA
TTTCCGATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12959.38 Da        Isoelectric Point: 4.6009

>AT181885 WP_212665884.1 NZ_CP064923:2585126-2585467 [Acaryochloris marina S15]
MKNMMEYQGYFGSVNFSDEDEVFFGKVEFIRSLISYEGTDVQSLKSAFHEAVDEYHSDCAENEIEPERPFKGSFNIRPGT
QLHRRAAITAQQRGINLNTLVTEALENYLQPSK

Download         Length: 342 bp

>AT181885 NZ_CP086196:c3832807-3832388 [Xanthomonas oryzae]
ATGATCACGTTTACACAAGGCAATCTACTGGAGTCTGGCGCAGAGGCGCTGGTCAACACCGTCAACACCGTCGGCGTGAT
GGGCAAGGGCATCGCGCTGATGTTCAAGGAGCGCTTCAAGGAGAACTTCCTCCGATATGCCGCCGCCTGCAAAGACAACC
AAGTGCGCATTGGCAAAATTTTCGTCACCGAAGTCAACGAACTGGACGGGCCACGCTGGATCATCAATTTTCCGACCAAA
CAGCACTGGCGTGGCGATTCCCGCATCGAATGGATCACTGAAGGATTGCAGGACTTGCACCGTTTTCTGATCGAGAACAA
AGTCAAATCCATTGCCATCCCGCCACTGGGCGCGGGCAATGGAGGATTGGACTGGGCCGAGGTGCGCCCACTGATCGAAG
AAGTACTAGGGAACCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References