Detailed information of TA system TA181883

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 1631237..1631743
• Replicon: chromosome
• Accession: NZ_CP064923
• Organism: Acaryochloris marina S15

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: I1H34_RS08195
• Protein ID: WP_283250055.1
• Coordinates: 1631534..1631743 (-)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: I1H34_RS08190
• Protein ID: WP_249369922.1
• Coordinates: 1631237..1631533 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I1H34_RS08170 (I1H34_08170)	1626899..1627429	+	531	WP_212665163.1	GNAT family N-acetyltransferase	-
I1H34_RS08175 (I1H34_08175)	1627464..1629941	+	2478	WP_212665164.1	ATP-dependent DNA helicase RecG	-
I1H34_RS08180 (I1H34_08180)	1630251..1630523	+	273	WP_212665165.1	hypothetical protein	-
I1H34_RS08185 (I1H34_08185)	1630607..1631038	-	432	WP_212666191.1	dUTP diphosphatase	-
I1H34_RS08190 (I1H34_08190)	1631237..1631533	-	297	WP_249369922.1	putative addiction module antidote protein	Antitoxin
I1H34_RS08195 (I1H34_08195)	1631534..1631743	-	210	WP_283250055.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I1H34_RS08200 (I1H34_08200)	1632420..1632944	-	525	WP_212665166.1	hypothetical protein	-
I1H34_RS08205 (I1H34_08205)	1633169..1633459	-	291	WP_212665167.1	DUF2288 domain-containing protein	-
I1H34_RS08210 (I1H34_08210)	1633604..1634815	+	1212	WP_212665168.1	saccharopine dehydrogenase NADP-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-65)

Antitoxin

• Uncharacterized protein HI1420 (4-95)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7572.61 Da
• Isoelectric Point: 8.5165

>T181883 WP_283250055.1 NZ_CP064923:c1631743-1631534 [Acaryochloris marina S15]
VQARIDRIEIGNFGDVAGVSELRIHYGPGYRVYFVQRGSVVVILLSGGDKSSQNADIKRAKEIAKPLED

Nucleotide

• Length: 210 bp

>T181883 NZ_CP086196:3183665-3183817 [Xanthomonas oryzae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10662.25 Da
• Isoelectric Point: 5.0758

>AT181883 WP_249369922.1 NZ_CP064923:c1631533-1631237 [Acaryochloris marina S15]
MMSISTTRWDSAAHLKTDEDIQLYLEACVEEAEDDPALIIHALGVVARAKNMSQLSRETGLSREGLYKALSVDGNPTFAI
VAKVTKALGFKLTIQPTV

Nucleotide

• Length: 297 bp

>AT181883 NZ_CP086196:3183881-3184015 [Xanthomonas oryzae]
ATGAAGCGTGCAATTGTGCTGCTCGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA