Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/AbrB(antitoxin)
Location 2870853..2871418 Replicon chromosome
Accession NZ_CP064908
Organism Synechococcus sp. CBW1107

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag I1E95_RS15045 Protein ID WP_197163606.1
Coordinates 2870853..2871197 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag I1E95_RS15050 Protein ID WP_197163608.1
Coordinates 2871194..2871418 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I1E95_RS15010 2866020..2866253 + 234 WP_197163581.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
I1E95_RS15015 2866253..2866639 + 387 WP_197163589.1 PIN domain-containing protein -
I1E95_RS15020 2866690..2867029 + 340 Protein_2950 HEPN domain-containing protein -
I1E95_RS15025 2866947..2867132 + 186 WP_197167589.1 hypothetical protein -
I1E95_RS15030 2867244..2867714 - 471 WP_197163591.1 hypothetical protein -
I1E95_RS15035 2867790..2868812 - 1023 WP_197167561.1 GDP-L-fucose synthase -
I1E95_RS15040 2868817..2869905 - 1089 WP_197163599.1 GDP-mannose 4,6-dehydratase -
I1E95_RS15045 2870853..2871197 - 345 WP_197163606.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I1E95_RS15050 2871194..2871418 - 225 WP_197163608.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I1E95_RS15055 2871744..2873555 + 1812 WP_197163609.1 SLC13 family permease -
I1E95_RS15060 2873623..2873799 + 177 WP_197163611.1 hypothetical protein -
I1E95_RS15065 2874063..2875070 - 1008 Protein_2959 IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-109)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12367.53 Da        Isoelectric Point: 9.4576

>T181880 WP_197163606.1 NZ_CP064908:c2871197-2870853 [Synechococcus sp. CBW1107]
VSAFKRYTVVRVPFPFTDRQAQKQRPALVLSQLCFQQSCGHLLLAMITSARQSSWPLDWPLEDLKAAGLPQPCLVRFKLF
TIDERLVLGGLGALAAADCAGVSAQLGKLLPSGT

Download         Length: 345 bp

>T181880 NZ_CP064908:c2871197-2870853 [Synechococcus sp. CBW1107]
GTGAGCGCCTTCAAGAGGTACACGGTGGTGCGAGTTCCGTTCCCATTCACTGATCGCCAGGCCCAGAAGCAGCGGCCGGC
GTTGGTGCTCTCACAGCTCTGCTTTCAGCAAAGCTGTGGCCATCTGCTGCTGGCGATGATCACATCAGCGCGGCAATCCT
CCTGGCCCCTCGATTGGCCCCTTGAAGATCTCAAGGCCGCGGGCCTGCCCCAACCCTGCCTGGTGCGCTTCAAGCTGTTC
ACCATTGATGAGCGGCTGGTGTTGGGTGGCCTGGGCGCTCTGGCCGCCGCCGATTGCGCCGGTGTGTCGGCCCAGCTGGG
CAAGCTGCTGCCCTCCGGGACCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8130.14 Da        Isoelectric Point: 4.2702

>AT181880 WP_197163608.1 NZ_CP064908:c2871418-2871194 [Synechococcus sp. CBW1107]
MEVATLTAKGQVTVPKAVREALGLRQGDQLSWELEDGSVRVRAVTPLDLAYLRGLESSLSEWSSPADEEAFREL

Download         Length: 225 bp

>AT181880 NZ_CP064908:c2871418-2871194 [Synechococcus sp. CBW1107]
ATGGAAGTCGCCACACTCACCGCCAAAGGACAGGTCACGGTGCCGAAGGCGGTGCGTGAGGCCCTGGGATTGCGGCAGGG
CGACCAGCTCAGTTGGGAACTGGAGGATGGCTCGGTGCGCGTGCGGGCGGTGACGCCGTTGGATCTGGCCTATCTCCGGG
GGCTGGAGAGCAGCCTTAGCGAGTGGAGTAGCCCGGCGGATGAGGAGGCGTTCCGCGAACTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References