Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/AbrB(antitoxin)
Location 2858799..2859364 Replicon chromosome
Accession NZ_CP064908
Organism Synechococcus sp. CBW1107

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag I1E95_RS14930 Protein ID WP_197163553.1
Coordinates 2858799..2859143 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag I1E95_RS14935 Protein ID WP_197163555.1
Coordinates 2859140..2859364 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I1E95_RS14880 2854237..2854527 - 291 Protein_2922 sugar nucleotide-binding protein -
I1E95_RS14885 2854600..2854809 + 210 WP_197163534.1 type II toxin-antitoxin system HicB family antitoxin -
I1E95_RS14890 2854806..2854991 + 186 WP_197163536.1 type II toxin-antitoxin system HicA family toxin -
I1E95_RS14895 2855027..2856010 - 984 WP_197167560.1 GDP-mannose 4,6-dehydratase -
I1E95_RS14900 2856087..2856278 + 192 WP_197163538.1 type II toxin-antitoxin system HicA family toxin -
I1E95_RS14905 2856275..2856487 + 213 WP_197163540.1 type II toxin-antitoxin system HicB family antitoxin -
I1E95_RS14910 2856503..2856960 - 458 Protein_2928 dTDP-4-dehydrorhamnose 3,5-epimerase -
I1E95_RS14915 2856979..2857101 - 123 Protein_2929 glucose-1-phosphate thymidylyltransferase -
I1E95_RS14920 2857520..2857711 + 192 WP_197163542.1 hypothetical protein -
I1E95_RS14925 2858148..2858336 - 189 WP_197163544.1 hypothetical protein -
I1E95_RS14930 2858799..2859143 - 345 WP_197163553.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I1E95_RS14935 2859140..2859364 - 225 WP_197163555.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I1E95_RS14940 2859750..2859929 - 180 WP_197163557.1 hypothetical protein -
I1E95_RS14945 2860134..2860751 + 618 WP_197163559.1 Uma2 family endonuclease -
I1E95_RS14950 2860690..2861070 - 381 WP_197163561.1 transposase family protein -
I1E95_RS14955 2861234..2861437 + 204 WP_197163563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
I1E95_RS14960 2861434..2861823 + 390 WP_197163565.1 type II toxin-antitoxin system VapC family toxin -
I1E95_RS14965 2862072..2862326 + 255 WP_197163567.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
I1E95_RS14970 2862335..2862745 + 411 WP_197163569.1 type II toxin-antitoxin system VapC family toxin -
I1E95_RS14975 2862765..2863175 - 411 Protein_2941 N-acetylmuramoyl-L-alanine amidase -
I1E95_RS14980 2863138..2863533 + 396 WP_197163571.1 hypothetical protein -
I1E95_RS14985 2863610..2863930 - 321 WP_197163572.1 hypothetical protein -
I1E95_RS14990 2863927..2864163 - 237 WP_197163574.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-109)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12413.50 Da        Isoelectric Point: 9.4161

>T181878 WP_197163553.1 NZ_CP064908:c2859143-2858799 [Synechococcus sp. CBW1107]
VSALERYTVVRVPFPFTDRQDQKQRPALVLSQPGFQRGCGHLLLAMITSARQSSWPLDWPLEDLKAAGLPQPCLVRFKLF
TLDERLVLGGLGALAAADCAGVSAQLGKLLPSRT

Download         Length: 345 bp

>T181878 NZ_CP086195:c3458098-3457175 [Xanthomonas oryzae]
ATGAACGAACCTGACAAGAGCAGGCGCACTGTTGCCGCGTCGGTTCGCGCCCGGCTGCTCAACAAGGCCCGCGCCGAAAG
ACTCGACTTCAACCTGCTGCTGACCCGCTACGCGCTGGAGCGCGTCCTTTACCGCCTGAGCGTTTCGGAGCAGCAGGGTC
AATTCTTGCTCAAAGGTGCGCTGCTGTTCGACATCTGGTTCGACATACCGCATCGCCCGACGCACGATGCCGACCTGCTG
GGCTTCGGCTCCACCGAGATCCCACATCTGGAAGACCTGTTCCGCAGAATCAGTCAAATCGCCAGCGATGACGGCATCGT
GTTTCAGGCCGACAGCGTGAAGGCCGCCGAAATCCGCAAGGAGGCCAACTACGCGGGCGTCCGTGTGACGATGATCGGCC
TGCTCGATGGCGCGCGCTGCACGGTGCAGATCGACATCGGTTTCGGCGACGCCGTGACGCCCGGCCCGGACAACGTGCAG
TACCCAGTCATCCTCGACGGCATGCCGCAGCCGCAACTGCGGGTCTATCCCCGCTACACCGTGGTCGCCGAAAAGCTGGA
AGCGATGGTCAAGCTCGGCATCCTCAACAGCCGGATGAAGGACTACTTCGACCTCTGGGTTCTCGCCGGACATTCCGACT
TCGACGGTGCGGTGCTGGCCACGGCCATTCGCGCCACGTTCGAGTGCAGGGGTACGGCCATCCCACCCGGCGCGCCGCTG
GGCCTCACCGATGAGTTCGGCCTGGACGAGCAGAAGACAAAGCAGTGGCAGGCGTTCCTGCGCAAGAACACCTTGGAGCC
GATGCCGCTGACCACGGTGATCGAAGCGCTGCGCGAATTCGTGCTGCCCGTGCTGGCCGCGCTCGCGGCAGGCGAAGGTT
TCGACCGCCAGTGGCGCGCGGGCGCGGGATGGGATGCGGCCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8015.94 Da        Isoelectric Point: 4.0785

>AT181878 WP_197163555.1 NZ_CP064908:c2859364-2859140 [Synechococcus sp. CBW1107]
MDVATLTAKGQVTVPKAVREALGLRQGDQLSWELEDGSVRVRAVAPLDLAYLQGLDSSLSDWSSPADEEAFRDL

Download         Length: 225 bp

>AT181878 NZ_CP086195:c3458694-3458095 [Xanthomonas oryzae]
ATGGACACGACCGTCGACAAGCTGCTGGAGCTGGTGCGCACGCGGGGACTTCTGCGCCCGCACGATCTGGCCCCACTGGG
CATCCCACGGGTGGCCCTGACGCGGGCCGTTCGGCGCGGGCAACTGGAGCGCGTCGGGCGCGGCCTGTACGGCCTGGTGG
CGCGTCCGGTGTCGGCCCACGGCACGCTGGCCGAAGTCGCGCGCCGCGTGCCCAAGGGCGTGGTCTGCCTGCTGTCGGCG
CTGCGCGTCCACGACCTGACGACCCAGGCCCCGTTCGAGGTGTGGCTGGCCATCGACAACAAGGCCGCTGCCCCGAAGCT
GGACTACCCGCCGCTACGTCTCGTGCGCTTCTCCGGGCCGGCGCTGAGCGAGGGCGTCGAGGAACACGTTGTTGATGGTG
TGCCCGTCCACGTGACCAGCGTCGCCAAGACCGTGGCCGACTGCTTCAAGTACCGCAACAAGATCGGCATCGACGTGGCG
CTGGAAGCGCTGCGCGAGGCGTGGGTTGCCCGGCGCATGACCAGCGACGAGATCTGGCACTACGCCAAGATCGACCGCGT
CGCCAACGTGATGCGTCCCTATCTGGAGAGCCTGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References