Detailed information of TA system TA181876

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 895642..896337
• Replicon: chromosome
• Accession: NZ_CP064908
• Organism: Synechococcus sp. CBW1107

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: I1E95_RS04815
• Protein ID: WP_197165933.1
• Coordinates: 895642..896079 (-)
• Length: 146 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: I1E95_RS04820
• Protein ID: WP_197165934.1
• Coordinates: 896095..896337 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I1E95_RS04780	890746..891657	+	912	WP_197165923.1	MoxR family ATPase	-
I1E95_RS04785	891644..892549	+	906	WP_197165925.1	hypothetical protein	-
I1E95_RS04790	892540..894441	+	1902	WP_197165927.1	DUF3488 and transglutaminase-like domain-containing protein	-
I1E95_RS04795	894351..894578	+	228	WP_197165928.1	nucleotidyltransferase substrate binding protein	-
I1E95_RS04800	894602..894760	+	159	WP_197165929.1	hypothetical protein	-
I1E95_RS04805	894808..895191	-	384	WP_197165930.1	type II toxin-antitoxin system VapC family toxin	-
I1E95_RS04810	895188..895409	-	222	WP_197165931.1	hypothetical protein	-
I1E95_RS04815	895642..896079	-	438	WP_197165933.1	PIN domain-containing protein	Toxin
I1E95_RS04820	896095..896337	-	243	WP_197165934.1	ribbon-helix-helix domain-containing protein	Antitoxin
I1E95_RS04825	896381..896725	-	345	WP_197165935.1	type II toxin-antitoxin system VapC family toxin	-
I1E95_RS04830	896725..896970	-	246	WP_197165936.1	hypothetical protein	-
I1E95_RS04835	897267..897491	-	225	WP_197165937.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
I1E95_RS04840	897604..898011	+	408	WP_197165938.1	nucleotidyltransferase domain-containing protein	-
I1E95_RS04845	897998..898298	+	301	Protein_956	hypothetical protein	-
I1E95_RS04850	898711..899967	+	1257	WP_197161565.1	IS256 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-133)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 146 a.a.
• Molecular weight: 16203.69 Da
• Isoelectric Point: 6.9111

>T181876 WP_197165933.1 NZ_CP064908:c896079-895642 [Synechococcus sp. CBW1107]
MRALLDINVIIALLDRGHVMHGAARRWMEQELGHGWATCPITENGVVRIMSQPAYPNHRPVAQVADRLAEACNHSSHAFW
PETISLLEPGLIRWERLLGPRQITDSYLLALAVTHGGRFVSFDQRIGLDLVPKASTEHLAMIESP

Nucleotide

• Length: 438 bp

>T181876 NZ_CP086195:c1199668-1199339 [Xanthomonas oryzae]
TTGCATCATGTCGCCGAACGCCGATGGCCGTTTCTGTTTACTGACAGCCACGCCTACTGCCAGTTGGCGAGCTTCTATTC
CGATTTATCTGATCTCGACAAGATCGACTGGCCGTTGCTCCAAGCACGCGATTTCCGGCGCGACCCAGACGACCCAGCCA
AGTTCGAGCGCTATCAGGCCGAGGCCCTGATTCACCGACACTTGCCGCTTGATGGCCTGCGCGGCATTGTGTGTCATACG
GATGGTTTGAAACAGACCATCGAGCGGCAACTCCAAGAGCGAAACCTGAAATTGCCGGTTCATACCCGCACCGATTGGTA
TTTCCGATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8542.64 Da
• Isoelectric Point: 4.7085

>AT181876 WP_197165934.1 NZ_CP064908:c896337-896095 [Synechococcus sp. CBW1107]
MRTTLDIEDDVLAAAKELARRQGLSAGKVVSQLLRSALSGGMEKAEAGSTVVAGFRPFQEASPKLVTNDQIDQLRDQDGL

Nucleotide

• Length: 243 bp

>AT181876 NZ_CP086195:c1199342-1198923 [Xanthomonas oryzae]
ATGATCACGTTTACACAAGGCAATCTACTGGAGTCTGGCGCAGAGGCGCTGGTCAACACCGTCAACACCGTCGGCGTGAT
GGGCAAGGGCATCGCGCTGATGTTCAAGGAGCGCTTCAAGGAGAACTTCCTCCGATATGCCGCCGCCTGCAAAGACAACC
AAGTGCGCATTGGCAAAATTTTCGTCACCGAAGTCAACGAACTGGACGGGCCACGCTGGATCATCAATTTTCCGACCAAA
CAGCACTGGCGTGGCGATTCCCGCATCGAATGGATCACTGAAGGATTGCAGGACTTGCACCGTTTTCTGATCGAGAACAA
AGTCAAATCCATTGCCATCCCGCCACTGGGCGCGGGCAATGGAGGATTGGACTGGGCCGAGGTGCGCCCACTGATCGAAG
AAGTACTAGGGAACCTCTGA