Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 4509078..4509699 Replicon chromosome
Accession NZ_CP064879
Organism Tolypothrix sp. PCC 7601

Toxin (Protein)


Gene name relE Uniprot ID A0A0D6L286
Locus tag HG267_RS18505 Protein ID WP_045867782.1
Coordinates 4509078..4509464 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D6L188
Locus tag HG267_RS18510 Protein ID WP_045867781.1
Coordinates 4509457..4509699 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HG267_RS18500 (HG267_18485) 4506938..4509001 + 2064 WP_081583873.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -
HG267_RS18505 (HG267_18490) 4509078..4509464 - 387 WP_045867782.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HG267_RS18510 (HG267_18495) 4509457..4509699 - 243 WP_045867781.1 hypothetical protein Antitoxin
HG267_RS18515 (HG267_18500) 4509833..4510414 - 582 WP_045867780.1 Uma2 family endonuclease -
HG267_RS18520 (HG267_18505) 4510462..4511112 - 651 WP_045867779.1 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE -
HG267_RS18525 (HG267_18510) 4511214..4511402 - 189 WP_045867778.1 ChaB family protein -
HG267_RS18530 (HG267_18515) 4511511..4512809 + 1299 WP_045867777.1 glutamate-1-semialdehyde 2,1-aminomutase -
HG267_RS18535 (HG267_18520) 4513016..4513825 - 810 WP_045867776.1 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase -
HG267_RS18540 (HG267_18525) 4513898..4514296 - 399 WP_045867775.1 metal-sensitive transcriptional regulator -
HG267_RS18545 (HG267_18530) 4514363..4514593 + 231 WP_045867774.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(20-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14526.40 Da        Isoelectric Point: 5.1813

>T181872 WP_045867782.1 NZ_CP064879:c4509464-4509078 [Tolypothrix sp. PCC 7601]
MVDRPLIQVDASLTFNRNIRTLAKKYRSIRNDIQPVIEQLQQGELPGDQIPGVGYTVFKLRVRNSDTQKGKSGGYRLIYY
VKTATGIILLTIYTKSEQVDIAADDIQSIITDYEQRTLTEQDDISDNS

Download         Length: 387 bp

>T181872 NZ_CP086194:c4611132-4610998 [Xanthomonas oryzae]
ATGAAGCGTGCAATTGTGCTGCTCGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8944.13 Da        Isoelectric Point: 3.9689

>AT181872 WP_045867781.1 NZ_CP064879:c4509699-4509457 [Tolypothrix sp. PCC 7601]
MKALKVMATINDQGQLTLDHPLLTDKNSRVEVIVLIPDEEVVLDDQSQAEVLADFRQAWHEAMTGQTIPVAQMWEGLEDG

Download         Length: 243 bp

>AT181872 NZ_CP086194:c4611348-4611196 [Xanthomonas oryzae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6L286

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6L188

References