Detailed information of TA system TA181869

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 2361344..2362322
• Replicon: chromosome
• Accession: NZ_CP064875
• Organism: Bacillus toyonensis strain P18

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: I0K03_RS11895
• Protein ID: WP_200204110.1
• Coordinates: 2361344..2362084 (+)
• Length: 247 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: J8KE32
• Locus tag: I0K03_RS11900
• Protein ID: WP_000588713.1
• Coordinates: 2362197..2362322 (+)
• Length: 42 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I0K03_RS11875	2357004..2357786	+	783	WP_000381783.1	class I SAM-dependent methyltransferase	-
I0K03_RS11880	2357967..2359643	-	1677	WP_000857156.1	alpha-keto acid decarboxylase family protein	-
I0K03_RS11885	2359770..2360252	+	483	WP_000191892.1	MarR family winged helix-turn-helix transcriptional regulator	-
I0K03_RS11890	2360420..2361157	+	738	WP_200204109.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
I0K03_RS11895	2361344..2362084	+	741	WP_200204110.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
I0K03_RS11900	2362197..2362322	+	126	WP_000588713.1	hypothetical protein	Antitoxin
I0K03_RS11905	2362398..2362574	+	177	WP_000808012.1	stage II sporulation protein SB	-
I0K03_RS11910	2362623..2363012	-	390	WP_000732295.1	YxeA family protein	-
I0K03_RS11915	2363256..2364725	+	1470	WP_000287565.1	beta-Ala-His dipeptidase	-
I0K03_RS11920	2365036..2365845	+	810	WP_000678381.1	C39 family peptidase	-
I0K03_RS11925	2365873..2366475	+	603	WP_000517300.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (11-244)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 247 a.a.
• Molecular weight: 28401.99 Da
• Isoelectric Point: 7.3530

>T181869 WP_200204110.1 NZ_CP064875:2361344-2362084 [Bacillus toyonensis]
MTISNIRIGLCILAIVFVVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIS
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTNIIQNINPAAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAANELNTGFRGIRSQFSITIPIEHIEQLNEQKAVQVENVGIIPAKIMNDVFIVIDGKKNSLQDRDFENVYNLTIH
HSYFSK

Nucleotide

• Length: 741 bp

>T181869 NZ_CP086194:1660635-1661558 [Xanthomonas oryzae]
ATGAACGAACCTGACAAGAGCAGGCGCACTGTTGCCGCGTCGGTTCGCGCCCGGCTGCTCAACAAGGCCCGCGCCGAAAG
ACTCGACTTCAACCTGCTGCTGACCCGCTACGCGCTGGAGCGCGTCCTTTACCGCCTGAGCGTTTCGGAGCAGCAGGGTC
AATTCTTGCTCAAAGGTGCGCTGCTGTTCGACATCTGGTTCGACATACCGCATCGCCCGACGCACGATGCCGACCTGCTG
GGCTTCGGCTCCACCGAGATCCCACATCTGGAAGACCTGTTCCGCAGAATCAGTCAAATCGCCAGCGATGACGGCATCGT
GTTTCAGGCCGACAGCGTGAAGGCCGCCGAAATCCGCAAGGAGGCCAACTACGCGGGCGTCCGTGTGACGATGATCGGCC
TGCTCGATGGCGCGCGCTGCACGGTGCAGATCGACATCGGTTTCGGCGACGCCGTGACGCCCGGCCCGGACAACGTGCAG
TACCCAGTCATCCTCGACGGCATGCCGCAGCCGCAACTGCGGGTCTATCCCCGCTACACCGTGGTCGCCGAAAAGCTGGA
AGCGATGGTCAAGCTCGGCATCCTCAACAGCCGGATGAAGGACTACTTCGACCTCTGGGTTCTCGCCGGACATTCCGACT
TCGACGGTGCGGTGCTGGCCACGGCCATTCGCGCCACGTTCGAGTGCAGGGGTACGGCCATCCCACCCGGCGCGCCGCTG
GGCCTCACCGATGAGTTCGGCCTGGACGAGCAGAAGACAAAGCAGTGGCAGGCGTTCCTGCGCAAGAACACCTTGGAGCC
GATGCCGCTGACCACGGTGATCGAAGCGCTGCGCGAATTCGTGCTGCCCGTGCTGGCCGCGCTCGCGGCAGGCGAAGGTT
TCGACCGCCAGTGGCGCGCGGGCGCGGGATGGGATGCGGCCTGA

Antitoxin

Protein

• Length: 42 a.a.
• Molecular weight: 4951.43 Da
• Isoelectric Point: 4.1079

>AT181869 WP_000588713.1 NZ_CP064875:2362197-2362322 [Bacillus toyonensis]
VIKDYDNDFFKEENEDTTDFSLIKGDTLQQVEKLEEELKRK

Nucleotide

• Length: 126 bp

>AT181869 NZ_CP086194:1660039-1660638 [Xanthomonas oryzae]
ATGGACACGACCGTCGACAAGCTGCTGGAGCTGGTGCGCACGCGGGGACTTCTGCGCCCGCACGATCTGGCCCCACTGGG
CATCCCACGGGTGGCCCTGACGCGGGCCGTTCGGCGCGGGCAACTGGAGCGCGTCGGGCGCGGCCTGTACGGCCTGGTGG
CGCGTCCGGTGTCGGCCCACGGCACGCTGGCCGAAGTCGCGCGCCGCGTGCCCAAGGGCGTGGTCTGCCTGCTGTCGGCG
CTGCGCGTCCACGACCTGACGACCCAGGCCCCGTTCGAGGTGTGGCTGGCCATCGACAACAAGGCCGCTGCCCCGAAGCT
GGACTACCCGCCGCTACGTCTCGTGCGCTTCTCCGGGCCGGCGCTGAGCGAGGGCGTCGAGGAACACGTTGTTGATGGTG
TGCCCGTCCACGTGACCAGCGTCGCCAAGACCGTGGCCGACTGCTTCAAGTACCGCAACAAGATCGGCATCGACGTGGCG
CTGGAAGCGCTGCGCGAGGCGTGGGTTGCCCGGCGCATGACCAGCGACGAGATCTGGCACTACGCCAAGATCGACCGCGT
CGCCAACGTGATGCGTCCCTATCTGGAGAGCCTGGCATGA

Structures

Antitoxin

• AlphaFold DB: J8KE32