Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2850159..2850776 Replicon chromosome
Accession NZ_CP064872
Organism Pantoea sp. SM3640

Toxin (Protein)


Gene name Hha Uniprot ID E0LTU7
Locus tag IV493_RS13355 Protein ID WP_003850458.1
Coordinates 2850561..2850776 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E1SGC9
Locus tag IV493_RS13350 Protein ID WP_013357010.1
Coordinates 2850159..2850536 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IV493_RS13320 2846474..2846728 + 255 WP_033782196.1 type B 50S ribosomal protein L31 -
IV493_RS13325 2846740..2846880 + 141 WP_009091664.1 type B 50S ribosomal protein L36 -
IV493_RS13330 2846926..2847804 - 879 WP_195857276.1 metal ABC transporter substrate-binding protein -
IV493_RS13335 2847824..2848663 - 840 WP_107319385.1 metal ABC transporter permease -
IV493_RS13340 2848660..2849328 - 669 WP_033782191.1 ABC transporter ATP-binding protein -
IV493_RS13345 2849658..2850011 + 354 WP_041456682.1 hypothetical protein -
IV493_RS13350 2850159..2850536 + 378 WP_013357010.1 Hha toxicity modulator TomB Antitoxin
IV493_RS13355 2850561..2850776 + 216 WP_003850458.1 hemolysin expression modulator Hha Toxin
IV493_RS13365 2851199..2851543 + 345 WP_013357009.1 MGMT family protein -
IV493_RS13370 2851545..2852102 - 558 WP_013357008.1 YbaY family lipoprotein -
IV493_RS13375 2852293..2853156 + 864 WP_013357007.1 acyl-CoA thioesterase II -
IV493_RS13380 2853215..2854501 - 1287 WP_195857277.1 ammonium transporter AmtB -
IV493_RS13385 2854536..2854874 - 339 WP_003850469.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8510.90 Da        Isoelectric Point: 9.4825

>T181867 WP_003850458.1 NZ_CP064872:2850561-2850776 [Pantoea sp. SM3640]
MNKTLTKTDYLMRLRRCRSLDTLERVIEKNKYELPEDELAVFYSAADHRLAELTMNKLYDKVPGSVWKFVR

Download         Length: 216 bp

>T181867 NZ_CP086193:c3812817-3812488 [Xanthomonas oryzae]
TTGCATCATGTCGCCGAACGCCGATGGCCGTTTCTGTTTACTGACAGCCACGCCTACTGCCAGTTGGCGAGCTTCTATTC
CGATTTATCTGATCTCGACAAGATCGACTGGCCGTTGCTCCAAGCACGCGATTTCCGGCGCGACCCAGACGACCCAGCCA
AGTTCGAGCGCTATCAGGCCGAGGCCCTGATTCACCGACACTTGCCGCTTGATGGCCTGCGCGGCATTGTGTGTCATACG
GATGGTTTGAAACAGACCATCGAGCGGCAACTCCAAGAGCGAAACCTGAAATTGCCGGTTCATACCCGCACCGATTGGTA
TTTCCGATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14650.28 Da        Isoelectric Point: 4.3976

>AT181867 WP_013357010.1 NZ_CP064872:2850159-2850536 [Pantoea sp. SM3640]
MDEYSPKRHDIAQLKYLCESLFDDSMATLTDSHHGWVNDPTSESNLQLNDLIEHIASFTMNYKIKHVEDEALISQIDEYL
DDTFMLFSNYGINSPDLQRWQRSAKRLFNLFTEECAFLQQPSHSL

Download         Length: 378 bp

>AT181867 NZ_CP086193:c3812491-3812072 [Xanthomonas oryzae]
ATGATCACGTTTACACAAGGCAATCTACTGGAGTCTGGCGCAGAGGCGCTGGTCAACACCGTCAACACCGTCGGCGTGAT
GGGCAAGGGCATCGCGCTGATGTTCAAGGAGCGCTTCAAGGAGAACTTCCTCCGATATGCCGCCGCCTGCAAAGACAACC
AAGTGCGCATTGGCAAAATTTTCGTCACCGAAGTCAACGAACTGGACGGGCCACGCTGGATCATCAATTTTCCGACCAAA
CAGCACTGGCGTGGCGATTCCCGCATCGAATGGATCACTGAAGGATTGCAGGACTTGCACCGTTTTCTGATCGAGAACAA
AGTCAAATCCATTGCCATCCCGCCACTGGGCGCGGGCAATGGAGGATTGGACTGGGCCGAGGTGCGCCCACTGATCGAAG
AAGTACTAGGGAACCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I5AGC3

Antitoxin

Source ID Structure
AlphaFold DB A0A5M7PH97

References