Detailed information of TA system TA181866

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 2134259..2134843
• Replicon: chromosome
• Accession: NZ_CP064872
• Organism: Pantoea sp. SM3640

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: IV493_RS09930
• Protein ID: WP_061062307.1
• Coordinates: 2134508..2134843 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: IV493_RS09925
• Protein ID: WP_033782896.1
• Coordinates: 2134259..2134507 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IV493_RS09905	2130500..2131111	-	612	WP_013357648.1	DUF2291 domain-containing protein	-
IV493_RS09910	2131157..2132092	-	936	WP_033732417.1	D-ribose ABC transporter substrate-binding protein	-
IV493_RS09915	2132148..2132945	-	798	WP_195857062.1	D-threitol dehydrogenase	-
IV493_RS09920	2133298..2134110	+	813	WP_195857063.1	DeoR/GlpR family DNA-binding transcription regulator	-
IV493_RS09925	2134259..2134507	+	249	WP_033782896.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
IV493_RS09930	2134508..2134843	+	336	WP_061062307.1	endoribonuclease MazF	Toxin
IV493_RS09935	2135329..2136168	-	840	WP_195857064.1	uroporphyrinogen-III C-methyltransferase	-
IV493_RS09940	2136168..2138786	-	2619	WP_195857065.1	nitrate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (5-111)

Antitoxin

• Antitoxin PemI-like (3-82)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 11986.95 Da
• Isoelectric Point: 9.2256

>T181866 WP_061062307.1 NZ_CP064872:2134508-2134843 [Pantoea sp. SM3640]
MVSRFVPEAGDIIWVDFDPTKGSEQAGHRPAVVLSPFAYNNKTGMCVCVPCTTHSKGYPFEVPISAEKDSVALSDQVKSI
AWKVRGAIKKGVVSASELQQIRGKIKVIIGL

Nucleotide

• Length: 336 bp

>T181866 NZ_CP086193:3153505-3153639 [Xanthomonas oryzae]
ATGAAGCGTGCAATTGTGCTGCTCGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9213.58 Da
• Isoelectric Point: 4.2459

>AT181866 WP_033782896.1 NZ_CP064872:2134259-2134507 [Pantoea sp. SM3640]
MIHGNVKRWGNSPAIRIPATLMQALNLNIDDEIKIDLVEGKLIIEPVKQEVGYSLAELLEGVTEENLHDPVEWGEPVGKE
IW

Nucleotide

• Length: 249 bp

>AT181866 NZ_CP086193:3153289-3153441 [Xanthomonas oryzae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA