Detailed information of TA system TA181865

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 1967443..1968073
• Replicon: chromosome
• Accession: NZ_CP064872
• Organism: Pantoea sp. SM3640

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: IV493_RS09095
• Protein ID: WP_095707240.1
• Coordinates: 1967891..1968073 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: IV493_RS09090
• Protein ID: WP_033783026.1
• Coordinates: 1967443..1967868 (-)
• Length: 142 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IV493_RS09075	1962667..1963821	+	1155	WP_013357795.1	efflux RND transporter periplasmic adaptor subunit	-
IV493_RS09080	1963834..1966986	+	3153	WP_013357794.1	multidrug efflux RND transporter permease subunit OqxB	-
IV493_RS09085	1967055..1967408	-	354	Protein_1763	type II toxin-antitoxin system HicB family antitoxin	-
IV493_RS09090	1967443..1967868	-	426	WP_033783026.1	hypothetical protein	Antitoxin
IV493_RS09095	1967891..1968073	-	183	WP_095707240.1	type II toxin-antitoxin system HicA family toxin	Toxin
IV493_RS09100	1968269..1968763	-	495	WP_013357792.1	Rrf2 family transcriptional regulator	-
IV493_RS09105	1968971..1970170	-	1200	WP_195858127.1	MFS transporter	-
IV493_RS09110	1970356..1971285	+	930	WP_147789263.1	DNA replication terminus site-binding protein	-
IV493_RS09115	1971327..1972724	-	1398	WP_195858128.1	class II fumarate hydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-82)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7076.24 Da
• Isoelectric Point: 10.8135

>T181865 WP_095707240.1 NZ_CP064872:c1968073-1967891 [Pantoea sp. SM3640]
MKYSEFRRWLIQQSAILTKHRSGSSHFKVFLGDRQSIFPDHGAKEMPECTRRKILKDLGL

Nucleotide

• Length: 183 bp

>T181865 NZ_CP086193:3153289-3153441 [Xanthomonas oryzae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA

Antitoxin

Protein

• Length: 142 a.a.
• Molecular weight: 15405.77 Da
• Isoelectric Point: 5.2470

>AT181865 WP_033783026.1 NZ_CP064872:c1967868-1967443 [Pantoea sp. SM3640]
MFNYAVSLTHDAKTDTYEVSCRDLPLLHSVGATVEEALSEAKDGLVTAISLEMDTRRPIPVASKPLEGEYIVSVPVLVAM
KAALYNAMIETGTRKVDLARQLGVNGPQVDRLLDVEHSSKVEKVEMALAQLGRKAQIEIRT

Nucleotide

• Length: 426 bp

>AT181865 NZ_CP086193:3153505-3153639 [Xanthomonas oryzae]
ATGAAGCGTGCAATTGTGCTGCTCGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA