Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1874259..1875820 Replicon chromosome
Accession NZ_CP064872
Organism Pantoea sp. SM3640

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag IV493_RS08650 Protein ID WP_195858087.1
Coordinates 1874507..1875820 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag IV493_RS08645 Protein ID WP_095707189.1
Coordinates 1874259..1874507 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IV493_RS08625 1869507..1871735 + 2229 WP_195858084.1 iron ABC transporter permease -
IV493_RS08630 1871732..1872793 + 1062 WP_195858085.1 ABC transporter ATP-binding protein -
IV493_RS08635 1872817..1873608 + 792 WP_095707188.1 inositol monophosphatase family protein -
IV493_RS08640 1873642..1874079 - 438 WP_195858086.1 GNAT family N-acetyltransferase -
IV493_RS08645 1874259..1874507 + 249 WP_095707189.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
IV493_RS08650 1874507..1875820 + 1314 WP_195858087.1 type II toxin-antitoxin system HipA family toxin Toxin
IV493_RS08655 1875925..1876131 + 207 WP_013357880.1 type II toxin-antitoxin system MqsA family antitoxin -
IV493_RS08660 1876169..1877056 - 888 WP_195858088.1 benzoate transporter -
IV493_RS08665 1877441..1878823 + 1383 WP_147789222.1 M24 family metallopeptidase -
IV493_RS08670 1878904..1879548 + 645 WP_147789223.1 LysE family translocator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49257.75 Da        Isoelectric Point: 8.4318

>T181864 WP_195858087.1 NZ_CP064872:1874507-1875820 [Pantoea sp. SM3640]
MQRLIAWMNGERVGVLTRQRNGAHEFQYDTGWLSNPLSRPLSLSLPLQVKAITSHAVINFFDNLLPDSPLIRDRIVARYQ
IKSRQPFDLLQEVGRDSVGATMLLPPDMPLPALQARYEVLDEARLESVLSAYQSDIPLGMLREETDFRISVAGAQEKTAL
LLTEEGWSIPAGATPTSHIIKLPIGEIKQPAATLDMRESVENEYLCLALARALGIDVPQATIIRAGKMRALAVERFDRRW
SRDRTRLIRLPQEDFCQALGLPSSTKYESDGGPGIAEIMQILMGSSNAIEDRYRFMMFQVFQWLTGATDGHAKNFSLFIE
RGGSYRLTPFYDVISAYPVLGGTGLNRRALKLAMGLRATKGKKTEIDKIFPRHFIATAKQVNFDRDSLQQIFDFFVREFP
KAVVSVREALPADFPQHIADAIFSHSLIMLERLRHND

Download         Length: 1314 bp

>T181864 NZ_CP086193:c2540609-2540328 [Xanthomonas oryzae]
GTGATCAGGAGCTTTATCGACAAGGACGCCGAAAAGATCTGGCTGGGTGAGCGTTCCCGCCGGTTGCCTGCCGACATCCA
ATTGGTCGCGCGCCGCAAGTTGCGCATGCTCAATGCCGCCGCACATCTCGACGATCTGCGGATCCCGCCCGCCAACCGGC
TGGAAGCGTTGAAGGGCCAGCGGCGCGGCCAGTACAGCATCCGGATCAACGATCAATGGCGCATCTGCTTCCGATGGATG
GAAGGCGATGTGGTCCAGGTCGAAATCGTCGATTACCACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9289.62 Da        Isoelectric Point: 6.4632

>AT181864 WP_095707189.1 NZ_CP064872:1874259-1874507 [Pantoea sp. SM3640]
MIYSPLQLANRLKLIRQRNGWTQSELAKKVGLKQATISHFENAPDSTSLATLFKLLQALEVSLDVVEKEKASAPQLHDED
EW

Download         Length: 249 bp

>AT181864 NZ_CP086193:c2540310-2540020 [Xanthomonas oryzae]
ATGACGGTCCTACCCAATATCCATCCTGGCGACATTCTGCTTGAGGAGTTTCTCGAGCCTCTGGGCATCAGCCAGAATGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGCACCTCCGAGCGCTTCTGGCTGGGCCTGCAGGCCGACTACGAGCTGGAACAGGCG
CATCGCGCGCTGGGCGATTTGCCGGCACGGATCAAGCGGCTGGCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References