Detailed information of TA system TA181860

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 407148..407695
• Replicon: chromosome
• Accession: NZ_CP064872
• Organism: Pantoea sp. SM3640

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: IV493_RS02030
• Protein ID: WP_195857657.1
• Coordinates: 407387..407695 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: E1SEY8
• Locus tag: IV493_RS02025
• Protein ID: WP_013359125.1
• Coordinates: 407148..407387 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IV493_RS02010	402508..403923	+	1416	WP_195857654.1	glucuronate isomerase	-
IV493_RS02015	403926..405374	+	1449	WP_195857655.1	tagaturonate reductase	-
IV493_RS02020	405379..406869	+	1491	WP_195857656.1	altronate dehydratase family protein	-
IV493_RS02025	407148..407387	+	240	WP_013359125.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
IV493_RS02030	407387..407695	+	309	WP_195857657.1	CcdB family protein	Toxin
IV493_RS02035	408037..409269	-	1233	WP_033784084.1	serine/threonine transporter SstT	-
IV493_RS02040	409505..410473	-	969	WP_013359123.1	TerC family protein	-
IV493_RS02045	410729..411715	-	987	WP_195857658.1	Gfo/Idh/MocA family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (10-79)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11620.53 Da
• Isoelectric Point: 7.2011

>T181860 WP_195857657.1 NZ_CP064872:407387-407695 [Pantoea sp. SM3640]
MQFDVYRNTGKAEIYPLVLDVQSNIIGRRKTRMAIPLFPHENYKGPRAERLTPILVIEGQKYVMMTHEMASVPEKALRED
VENISGQAVVIKSALDFLFDGI

Nucleotide

• Length: 309 bp

>T181860 NZ_CP086191:c2753618-2753289 [Xanthomonas oryzae]
TTGCATCATGTCGCCGAACGCCGATGGCCGTTTCTGTTTACTGACAGCCACGCCTACTGCCAGTTGGCGAGCTTCTATTC
CGATTTATCTGATCTCGACAAGATCGACTGGCCGTTGCTCCAAGCACGCGATTTCCGGCGCGACCCAGACGACCCAGCCA
AGTTCGAGCGCTATCAGGCCGAGGCCCTGATTCACCGACACTTGCCGCTTGATGGCCTGCGCGGCATTGTGTGTCATACG
GATGGTTTGAAACAGACCATCGAGCGGCAACTCCAAGAGCGAAACCTGAAATTGCCGGTTCATACCCGCACCGATTGGTA
TTTCCGATGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8840.89 Da
• Isoelectric Point: 5.6032

>AT181860 WP_013359125.1 NZ_CP064872:407148-407387 [Pantoea sp. SM3640]
MGEVATKPTKNINVTIDTKLALEAREAGINFSQTLAKAVRAELKSLAAERWKHENADAIDYLNQLSDEHGLFSDEHRTF

Nucleotide

• Length: 240 bp

>AT181860 NZ_CP086191:c2753292-2752873 [Xanthomonas oryzae]
ATGATCACGTTTACACAAGGCAATCTACTGGAGTCTGGCGCAGAGGCGCTGGTCAACACCGTCAACACCGTCGGCGTGAT
GGGCAAGGGCATCGCGCTGATGTTCAAGGAGCGCTTCAAGGAGAACTTCCTCCGATATGCCGCCGCCTGCAAAGACAACC
AAGTGCGCATTGGCAAAATTTTCGTCACCGAAGTCAACGAACTGGACGGGCCACGCTGGATCATCAATTTTCCGACCAAA
CAGCACTGGCGTGGCGATTCCCGCATCGAATGGATCACTGAAGGATTGCAGGACTTGCACCGTTTTCTGATCGAGAACAA
AGTCAAATCCATTGCCATCCCGCCACTGGGCGCGGGCAATGGAGGATTGGACTGGGCCGAGGTGCGCCCACTGATCGAAG
AAGTACTAGGGAACCTCTGA

Structures

Antitoxin

• AlphaFold DB: E1SEY8