Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 955780..956319 Replicon chromosome
Accession NZ_CP064868
Organism Mammaliicoccus sciuri strain 82104

Toxin (Protein)


Gene name mazF Uniprot ID A0A418JBZ2
Locus tag IYN86_RS04640 Protein ID WP_048540867.1
Coordinates 955948..956319 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A657XHG2
Locus tag IYN86_RS04635 Protein ID WP_025904510.1
Coordinates 955780..955947 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IYN86_RS04610 951662..952141 + 480 WP_058612364.1 PH domain-containing protein -
IYN86_RS04615 952131..953651 + 1521 WP_058612363.1 PH domain-containing protein -
IYN86_RS04620 953641..954105 + 465 WP_218697259.1 PH domain-containing protein -
IYN86_RS04625 954137..954499 + 363 WP_058591084.1 holo-ACP synthase -
IYN86_RS04630 954547..955695 + 1149 WP_248559334.1 alanine racemase -
IYN86_RS04635 955780..955947 + 168 WP_025904510.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
IYN86_RS04640 955948..956319 + 372 WP_048540867.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IYN86_RS04645 956416..957420 + 1005 WP_048540866.1 PP2C family protein-serine/threonine phosphatase -
IYN86_RS04650 957525..957848 + 324 WP_025904513.1 anti-sigma factor antagonist -
IYN86_RS04655 957853..958329 + 477 WP_025904514.1 anti-sigma B factor RsbW -
IYN86_RS04660 958304..959074 + 771 WP_037589755.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13653.83 Da        Isoelectric Point: 9.9193

>T181853 WP_048540867.1 NZ_CP064868:955948-956319 [Mammaliicoccus sciuri]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDIAIAISLNLTLQQKFDTLGNT

Download         Length: 372 bp

>T181853 NZ_CP086188:c4190531-4190280 [Xanthomonas oryzae]
ATGCTACGGCTGCGTGAATTCCTGAGGCCGAAGAATCCCGATGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGT
CCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAGAAGATCTGTCTGAACAGTATCGGGAGTGGCTTATCGATT
TTGGGGATAGCGGCTATGTGGCTCGGTACCGCTTCGATGGGGATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAA
GCGGGGTACTGA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6136.65 Da        Isoelectric Point: 4.0121

>AT181853 WP_025904510.1 NZ_CP064868:955780-955947 [Mammaliicoccus sciuri]
MTSLTQNRTQSLEQTLKEGYRSMADLNLSLASEAYYCECEACDSNESHIASQQGE

Download         Length: 168 bp

>AT181853 NZ_CP086188:c4190836-4190558 [Xanthomonas oryzae]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCAGAGTCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCATGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCGAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A418JBZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A657XHG2

References