Detailed information of TA system TA181852

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2510097..2510764
• Replicon: chromosome
• Accession: NZ_CP064860
• Organism: Companilactobacillus futsaii strain CQ16Z11

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: ITJ83_RS12200
• Protein ID: WP_195701506.1
• Coordinates: 2510582..2510764 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: ITJ83_RS12195
• Protein ID: WP_195701505.1
• Coordinates: 2510097..2510552 (-)
• Length: 152 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ITJ83_RS12180	2505807..2507258	-	1452	WP_149029846.1	IS1182 family transposase	-
ITJ83_RS12185	2507422..2508831	-	1410	WP_195701504.1	SLAP domain-containing protein	-
ITJ83_RS12190	2509077..2509997	+	921	WP_149029770.1	IS30 family transposase	-
ITJ83_RS12195	2510097..2510552	-	456	WP_195701505.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ITJ83_RS12200	2510582..2510764	-	183	WP_195701506.1	type II toxin-antitoxin system HicA family toxin	Toxin
ITJ83_RS12205	2510961..2511290	-	330	WP_195702110.1	metal-sulfur cluster assembly factor	-
ITJ83_RS12210	2511295..2512686	-	1392	WP_195701507.1	Fe-S cluster assembly protein SufB	-
ITJ83_RS12215	2512679..2513125	-	447	WP_195701508.1	SUF system NifU family Fe-S cluster assembly protein	-
ITJ83_RS12220	2513122..2514351	-	1230	WP_195701509.1	cysteine desulfurase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2514542..2515897	1355

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6674.05 Da
• Isoelectric Point: 11.2565

>T181852 WP_195701506.1 NZ_CP064860:c2510764-2510582 [Companilactobacillus futsaii]
MPMTQKEMVKLLKTNGWAKTIGGKGSHIKMSKLGKRPITVPHGELNKFTERAIKKEAGLK

Nucleotide

• Length: 183 bp

>T181852 NZ_CP086188:1602578-1602712 [Xanthomonas oryzae]
ATGAAGCGTGCAATTGTGCTGCTCGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin

Protein

• Length: 152 a.a.
• Molecular weight: 16994.32 Da
• Isoelectric Point: 4.9202

>AT181852 WP_195701505.1 NZ_CP064860:c2510552-2510097 [Companilactobacillus futsaii]
MLVSYPALFYYDQSEKVPFFITFPDFTNSGTQGNDVTDAMSMATDWLGINVADYLENNRPLPAPSTLEEISLAKNNPYPE
DLKYDSKRSFKSMVLVDLDSYLKGDIKIKKTVSIPKWADRAGADLHINYSATLTEAIAQAKMLHDSKIMNK

Nucleotide

• Length: 456 bp

>AT181852 NZ_CP086188:1602362-1602514 [Xanthomonas oryzae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA