Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1899554..1900166 Replicon chromosome
Accession NZ_CP064855
Organism Erwinia amylovora strain Ea1/79Sm

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag IYV53_RS08795 Protein ID WP_012906750.1
Coordinates 1899554..1899733 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID D4I356
Locus tag IYV53_RS08800 Protein ID WP_004157632.1
Coordinates 1899756..1900166 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IYV53_RS08775 1895112..1896062 + 951 WP_004157624.1 DUF1471 domain-containing protein -
IYV53_RS08780 1896270..1897661 + 1392 WP_004157625.1 amino acid permease -
IYV53_RS08785 1897665..1898129 - 465 WP_004157626.1 hypothetical protein -
IYV53_RS08790 1898306..1899034 + 729 WP_004157629.1 two-component system response regulator RstA -
IYV53_RS08795 1899554..1899733 + 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
IYV53_RS08800 1899756..1900166 + 411 WP_004157632.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IYV53_RS08805 1900222..1901223 + 1002 WP_004157633.1 acyltransferase -
IYV53_RS08810 1902094..1902306 - 213 WP_004157635.1 hypothetical protein -
IYV53_RS08815 1902564..1902737 - 174 WP_004157636.1 hypothetical protein -
IYV53_RS08820 1902832..1903005 - 174 WP_013036045.1 hypothetical protein -
IYV53_RS08825 1903016..1903288 - 273 WP_004157637.1 hypothetical protein -
IYV53_RS08830 1903894..1904508 + 615 WP_004166850.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1893392..1904508 11116


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T181843 WP_012906750.1 NZ_CP064855:1899554-1899733 [Erwinia amylovora]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T181843 NZ_CP086184:c4165346-4165194 [Xanthomonas oryzae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14829.76 Da        Isoelectric Point: 4.3623

>AT181843 WP_004157632.1 NZ_CP064855:1899756-1900166 [Erwinia amylovora]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDNYQDAIESAREAIDAHIELLVEDGEAVPEATSVENWLADPDYVGVVWALVD
VDVTRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Download         Length: 411 bp

>AT181843 NZ_CP086184:c4165130-4164996 [Xanthomonas oryzae]
ATGAAGCGTGCAATTGTGCTGCTCGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A830ZVY0

References