Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4147108..4147943 Replicon chromosome
Accession NZ_CP064847
Organism Escherichia coli strain 20

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3P1YKV1
Locus tag IPT86_RS19995 Protein ID WP_016240657.1
Coordinates 4147108..4147485 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3L4CDD9
Locus tag IPT86_RS20000 Protein ID WP_016240658.1
Coordinates 4147575..4147943 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IPT86_RS19960 4142147..4143988 + 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -
IPT86_RS19965 4144047..4144610 + 564 WP_001183949.1 NADAR family protein -
IPT86_RS19970 4144667..4145173 - 507 WP_000228936.1 G/U mismatch-specific DNA glycosylase -
IPT86_RS19980 4145472..4146317 - 846 WP_001280435.1 DUF4942 domain-containing protein -
IPT86_RS19985 4146414..4146611 - 198 WP_000839263.1 DUF957 domain-containing protein -
IPT86_RS19990 4146623..4147111 - 489 WP_016240656.1 hypothetical protein -
IPT86_RS19995 4147108..4147485 - 378 WP_016240657.1 TA system toxin CbtA family protein Toxin
IPT86_RS20000 4147575..4147943 - 369 WP_016240658.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IPT86_RS20005 4147993..4148637 - 645 WP_016240659.1 hypothetical protein -
IPT86_RS20010 4148656..4148877 - 222 WP_000692353.1 DUF987 domain-containing protein -
IPT86_RS20015 4148946..4149422 - 477 WP_016240660.1 RadC family protein -
IPT86_RS20020 4149437..4149922 - 486 WP_000214317.1 antirestriction protein -
IPT86_RS20025 4150013..4150831 - 819 WP_001234702.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14192.16 Da        Isoelectric Point: 8.2905

>T181833 WP_016240657.1 NZ_CP064847:c4147485-4147108 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T181833 NZ_CP086182:4853662-4853943 [Xanthomonas oryzae]
GTGATCAGGAGCTTTATCGACAAGGACGCCGAAAAGATCTGGCTGGGTGAGCGTTCCCGCCGGTTGCCTGCCGACATCCA
ATTGGTCGCGCGCCGCAAGTTGCGCATGCTCAATGCCGCCGCACATCTCGACGATCTGCGGATCCCGCCCGCCAACCGGC
TGGAAGCGTTGAAGGGCCAGCGGCGCGGCCAGTACAGCATCCGGATCAACGATCAATGGCGCATCTGCTTCCGATGGATG
GAAGGCGATGTGGTCCAGGTCGAAATCGTCGATTACCACTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13876.58 Da        Isoelectric Point: 5.9652

>AT181833 WP_016240658.1 NZ_CP064847:c4147943-4147575 [Escherichia coli]
VSDTFHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRDGIRGRFRDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGVTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT181833 NZ_CP086182:4853961-4854251 [Xanthomonas oryzae]
ATGACGGTCCTACCCAATATCCATCCTGGCGACATTCTGCTTGAGGAGTTTCTCGAGCCTCTGGGCATCAGCCAGAATGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGCACCTCCGAGCGCTTCTGGCTGGGCCTGCAGGCCGACTACGAGCTGGAACAGGCG
CATCGCGCGCTGGGCGATTTGCCGGCACGGATCAAGCGGCTGGCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3P1YKV1

Antitoxin

Source ID Structure
AlphaFold DB A0A3L4CDD9

References