Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 702110..702660 Replicon chromosome
Accession NZ_CP064847
Organism Escherichia coli strain 20

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag IPT86_RS03405 Protein ID WP_075861930.1
Coordinates 702346..702660 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag IPT86_RS03400 Protein ID WP_075861929.1
Coordinates 702110..702343 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IPT86_RS03375 697184..697471 + 288 WP_000203741.1 ferredoxin-like protein FixX -
IPT86_RS03380 697529..698860 + 1332 WP_001183201.1 MFS transporter -
IPT86_RS03385 698968..699498 + 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
IPT86_RS03390 699491..701353 + 1863 WP_000377117.1 glutathione-regulated potassium-efflux system protein KefC -
IPT86_RS03395 701545..702024 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
IPT86_RS03400 702110..702343 + 234 WP_075861929.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
IPT86_RS03405 702346..702660 + 315 WP_075861930.1 CcdB family protein Toxin
IPT86_RS03410 702657..703505 - 849 WP_075861931.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
IPT86_RS03415 703512..703889 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
IPT86_RS03420 703892..704713 - 822 WP_075861932.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
IPT86_RS03425 704710..705699 - 990 WP_075861933.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
IPT86_RS03430 705699..706985 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11755.77 Da        Isoelectric Point: 9.0851

>T181816 WP_075861930.1 NZ_CP064847:702346-702660 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIISEINRRIVIPLTPIERFSRIRPPERLNPILLLIDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T181816 NZ_CP086180:1100831-1101160 [Xanthomonas oryzae]
TTGCATCATGTCGCCGAACGCCGATGGCCGTTTCTGTTTACTGACAGCCACGCCTACTGCCAGTTGGCGAGCTTCTATTC
CGATTTATCTGATCTCGACAAGATCGACTGGCCGTTGCTCCAAGCACGCGATTTCCGGCGCGACCCAGACGACCCAGCCA
AGTTCGAGCGCTATCAGGCCGAGGCCCTGATTCACCGACACTTGCCGCTTGATGGCCTGCGCGGCATTGTGTGTCATACG
GATGGTTTGAAACAGACCATCGAGCGGCAACTCCAAGAGCGAAACCTGAAATTGCCGGTTCATACCCGCACCGATTGGTA
TTTCCGATGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8618.59 Da        Isoelectric Point: 5.0789

>AT181816 WP_075861929.1 NZ_CP064847:702110-702343 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAETRWREENTEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT181816 NZ_CP086180:1101157-1101576 [Xanthomonas oryzae]
ATGATCACGTTTACACAAGGCAATCTACTGGAGTCTGGCGCAGAGGCGCTGGTCAACACCGTCAACACCGTCGGCGTGAT
GGGCAAGGGCATCGCGCTGATGTTCAAGGAGCGCTTCAAGGAGAACTTCCTCCGATATGCCGCCGCCTGCAAAGACAACC
AAGTGCGCATTGGCAAAATTTTCGTCACCGAAGTCAACGAACTGGACGGGCCACGCTGGATCATCAATTTTCCGACCAAA
CAGCACTGGCGTGGCGATTCCCGCATCGAATGGATCACTGAAGGATTGCAGGACTTGCACCGTTTTCTGATCGAGAACAA
AGTCAAATCCATTGCCATCCCGCCACTGGGCGCGGGCAATGGAGGATTGGACTGGGCCGAGGTGCGCCCACTGATCGAAG
AAGTACTAGGGAACCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References