Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 492019..492541 Replicon chromosome
Accession NZ_CP064847
Organism Escherichia coli strain 20

Toxin (Protein)


Gene name relE Uniprot ID V0SDB6
Locus tag IPT86_RS02435 Protein ID WP_001105432.1
Coordinates 492251..492541 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag IPT86_RS02430 Protein ID WP_000212715.1
Coordinates 492019..492261 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IPT86_RS02410 487933..489306 + 1374 WP_001219814.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
IPT86_RS02415 489389..489940 - 552 WP_000166270.1 ribosome-associated protein -
IPT86_RS02420 490033..491385 + 1353 WP_075861635.1 metalloprotease PmbA -
IPT86_RS02425 491441..491827 + 387 WP_001232253.1 cytochrome b562 -
IPT86_RS02430 492019..492261 + 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IPT86_RS02435 492251..492541 + 291 WP_001105432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IPT86_RS02440 492542..493006 - 465 WP_001009180.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IPT86_RS02445 493191..495329 - 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
IPT86_RS02450 495723..497378 - 1656 WP_001361372.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11311.21 Da        Isoelectric Point: 10.0238

>T181814 WP_001105432.1 NZ_CP064847:492251-492541 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRLVYSVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T181814 NZ_CP086179:3241776-3242042 [Streptomyces fungicidicus]
GTGAGTAGCGGCTACCGCACCGTCTTCCGGCCGGAGGCTCAGGCGGAGCTTCGCAAGATTCCCCGGGACATGGCCCTGAG
GATCCTGGTCAAACTGACGGAACTGGAAACGGACCCGCTCGGCTTCCGCACCACGGCGCTCGTCTCCCGGCCCGACCGGC
GCCGGCTCCGTGTCGGCGACTACCGCGTCATCTACACGATCGACAACGGCGAGTTGACGGTCTGGGTCGTTCATGTCGGA
CACCGCTCCACGGTATACGACACCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT181814 WP_000212715.1 NZ_CP064847:492019-492261 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT181814 NZ_CP086179:3241517-3241783 [Streptomyces fungicidicus]
ATGACCGAGATGCCCATAGAGTCCATTCGTGACGTGCGCGCCCACCTGGCCGAGGTGGTCGAACGGGCGGACCGGGACGA
CACGCCCACGGTCATCACCCGGCGAGGCAAGCAGGTGGCCGCAGTCGTGTCGATGGAGGTCCTTCGCAAGTACCAGGAAT
GGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCGAACCCGGCAGCCGGTATCCCGATCGAGGACGTCATG
CGGGAGACGCTGGAGCGCGGTGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SDB6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References