Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 313799..314634 Replicon chromosome
Accession NZ_CP064847
Organism Escherichia coli strain 20

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0A1A9A5
Locus tag IPT86_RS01490 Protein ID WP_001564063.1
Coordinates 313799..314176 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0K5N986
Locus tag IPT86_RS01495 Protein ID WP_021553056.1
Coordinates 314266..314634 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IPT86_RS01470 310166..311704 - 1539 WP_001187178.1 lysine decarboxylation/transport transcriptional activator CadC -
IPT86_RS01475 312453..313295 - 843 Protein_282 DUF4942 domain-containing protein -
IPT86_RS01480 313380..313574 - 195 WP_024181941.1 DUF957 domain-containing protein -
IPT86_RS01485 313653..313802 - 150 Protein_284 hypothetical protein -
IPT86_RS01490 313799..314176 - 378 WP_001564063.1 TA system toxin CbtA family protein Toxin
IPT86_RS01495 314266..314634 - 369 WP_021553056.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IPT86_RS01500 314797..315018 - 222 WP_000692345.1 DUF987 domain-containing protein -
IPT86_RS01505 315083..315559 - 477 WP_021553055.1 RadC family protein -
IPT86_RS01510 315575..316054 - 480 WP_001564060.1 antirestriction protein -
IPT86_RS01515 316320..317138 - 819 WP_001564059.1 DUF945 domain-containing protein -
IPT86_RS01520 317228..317461 - 234 WP_001278293.1 DUF905 family protein -
IPT86_RS01525 317467..318144 - 678 WP_001564058.1 hypothetical protein -
IPT86_RS01530 318295..318975 - 681 WP_001278649.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 302677..348461 45784


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14094.09 Da        Isoelectric Point: 7.8045

>T181812 WP_001564063.1 NZ_CP064847:c314176-313799 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T181812 NZ_CP086178:4033786-4034196 [Streptomyces fungicidicus]
GTGATCTACCTGCTCGACACGTCCGGCCTGGTCCGGCTGCTCCGCGATCCGAAACTGCAATCGGCCTGGTACGACGCGAT
CGATGCCGGGGCCATCGCATCCTGCTACGTGCAACGCGCCGAGTTCCTCCACAGTGCCCGGAACGGGCGCGAGTACGACG
AGATCACGGAAATGTTCACCGACCTCTACCCCGACGTGTCGGTACCGAAGAACGCGGGGCGCTGGATCGGCGCGGTGCAG
CACCGCATGGCTCGGGCAGGGGAGCATCGCAGCGCCTCGGCGGTGGACCTCCTCATCGCCGCCACCGCGGCCCACCATGG
CCTGGCTGTCCTCCACGATGATGCCGACTATCGGGCGATTGCCCGGCACGCATCCGACCTGACCGAGCACAACGTCCACG
ACATCGCTTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13615.39 Da        Isoelectric Point: 7.0264

>AT181812 WP_021553056.1 NZ_CP064847:c314634-314266 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGNRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT181812 NZ_CP086178:4033568-4033789 [Streptomyces fungicidicus]
ATGTCCGTGACTCAGATTGACATCGACGACGACGCCCTGGAGCGAGCCATGGCTCTGGCCCACGTCCGGACCAAGAAGGA
GGCGGTCAACCTCGCTCTGAATTTCTATGCCGAGCAGCAGGAGCGTGCGGCGCGCATCAGCCGTCACTTCGAGCGTGCCC
GTGAGTGGGGTGCCGTTGAGGACGCCGAGCGTCTGCACAGGGCGGAGAAGCGCAACCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A1A9A5

Antitoxin

Source ID Structure
AlphaFold DB A0A0K5N986

References