Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3845812..3846629 Replicon chromosome
Accession NZ_CP064833
Organism Morganella morganii subsp. morganii strain 715394

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag IZ181_RS18400 Protein ID WP_015422406.1
Coordinates 3845812..3846318 (-) Length 169 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag IZ181_RS18405 Protein ID WP_032097998.1
Coordinates 3846321..3846629 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IZ181_RS18365 (IZ181_18365) 3841171..3841794 - 624 WP_004236525.1 thiol:disulfide interchange protein DsbA -
IZ181_RS18370 (IZ181_18370) 3841813..3842808 - 996 WP_048821883.1 serine/threonine protein kinase -
IZ181_RS18375 (IZ181_18375) 3842808..3843077 - 270 WP_036415677.1 YihD family protein -
IZ181_RS19470 3843298..3843870 + 573 Protein_3591 molybdenum cofactor guanylyltransferase MobA -
IZ181_RS19475 3843877..3844395 + 519 WP_223302449.1 molybdopterin-guanine dinucleotide biosynthesis protein MobB -
IZ181_RS18385 (IZ181_18385) 3844610..3844912 + 303 WP_004240743.1 HdeA/HdeB family chaperone -
IZ181_RS18390 (IZ181_18390) 3845040..3845561 + 522 WP_015422407.1 isopentenyl-diphosphate Delta-isomerase -
IZ181_RS18395 3845558..3845698 + 141 WP_004236531.1 hypothetical protein -
IZ181_RS18400 (IZ181_18400) 3845812..3846318 - 507 WP_015422406.1 GNAT family N-acetyltransferase Toxin
IZ181_RS18405 (IZ181_18405) 3846321..3846629 - 309 WP_032097998.1 DUF1778 domain-containing protein Antitoxin
IZ181_RS18410 (IZ181_18410) 3846761..3848113 - 1353 WP_032098064.1 glutathione-disulfide reductase -
IZ181_RS18415 (IZ181_18415) 3848182..3849024 - 843 WP_004236535.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
IZ181_RS18420 (IZ181_18420) 3849214..3849603 + 390 WP_004236536.1 DUF1090 domain-containing protein -
IZ181_RS18425 (IZ181_18425) 3850015..3851007 + 993 WP_032098000.1 inner membrane protein YhjD -
IZ181_RS18430 (IZ181_18430) 3851115..3851321 + 207 WP_004236540.1 4-oxalocrotonate tautomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-143)

Antitoxin

Vibrio phage ICP1, Orf50

(21-94)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 18565.43 Da        Isoelectric Point: 9.9508

>T181809 WP_015422406.1 NZ_CP064833:c3846318-3845812 [Morganella morganii subsp. morganii]
MNLTAPEPLQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPE
IPVILPGRLAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQ
LATGIYSE

Download         Length: 507 bp

>T181809 NZ_CP086177:4034221-4034631 [Streptomyces fungicidicus]
GTGATCTACCTGCTCGACACGTCCGGCCTGGTCCGGCTGCTCCGCGATCCGAAACTGCAATCGGCCTGGTACGACGCGAT
CGATGCCGGGGCCATCGCATCCTGCTACGTGCAACGCGCCGAGTTCCTCCACAGTGCCCGGAACGGGCGCGAGTACGACG
AGATCACGGAAATGTTCACCGACCTCTACCCCGACGTGTCGGTACCGAAGAACGCGGGGCGCTGGATCGGCGCGGTGCAG
CACCGCATGGCTCGGGCAGGGGAGCATCGCAGCGCCTCGGCGGTGGACCTCCTCATCGCCGCCACCGCGGCCCACCATGG
CCTGGCTGTCCTCCACGATGATGCCGACTATCGGGCGATTGCCCGGCACGCATCCGACCTGACCGAGCACAACGTCCACG
ACATCGCTTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11469.12 Da        Isoelectric Point: 8.6397

>AT181809 WP_032097998.1 NZ_CP064833:c3846629-3846321 [Morganella morganii subsp. morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLAKAPWEK

Download         Length: 309 bp

>AT181809 NZ_CP086177:4034003-4034224 [Streptomyces fungicidicus]
ATGTCCGTGACTCAGATTGACATCGACGACGACGCCCTGGAGCGAGCCATGGCTCTGGCCCACGTCCGGACCAAGAAGGA
GGCGGTCAACCTCGCTCTGAATTTCTATGCCGAGCAGCAGGAGCGTGCGGCGCGCATCAGCCGTCACTTCGAGCGTGCCC
GTGAGTGGGGTGCCGTTGAGGACGCCGAGCGTCTGCACAGGGCGGAGAAGCGCAACCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References