Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 724819..725445 Replicon chromosome
Accession NZ_CP064833
Organism Morganella morganii subsp. morganii strain 715394

Toxin (Protein)


Gene name Hha Uniprot ID A0A0A2RCL2
Locus tag IZ181_RS03255 Protein ID WP_024474604.1
Coordinates 724819..725022 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J7U1S9
Locus tag IZ181_RS03260 Protein ID WP_004236473.1
Coordinates 725086..725445 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IZ181_RS03235 (IZ181_03235) 721375..721713 + 339 WP_004236467.1 P-II family nitrogen regulator -
IZ181_RS03240 (IZ181_03240) 721733..723022 + 1290 WP_036422539.1 ammonium transporter AmtB -
IZ181_RS03245 (IZ181_03245) 723083..723946 - 864 WP_163652868.1 acyl-CoA thioesterase II -
IZ181_RS03255 (IZ181_03255) 724819..725022 - 204 WP_024474604.1 HHA domain-containing protein Toxin
IZ181_RS03260 (IZ181_03260) 725086..725445 - 360 WP_004236473.1 Hha toxicity modulator TomB Antitoxin
IZ181_RS03265 (IZ181_03265) 726008..729184 - 3177 WP_004240375.1 efflux RND transporter permease subunit -
IZ181_RS03270 (IZ181_03270) 729199..730395 - 1197 WP_015422955.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8073.39 Da        Isoelectric Point: 6.9770

>T181808 WP_024474604.1 NZ_CP064833:c725022-724819 [Morganella morganii subsp. morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T181808 NZ_CP086177:3242212-3242478 [Streptomyces fungicidicus]
GTGAGTAGCGGCTACCGCACCGTCTTCCGGCCGGAGGCTCAGGCGGAGCTTCGCAAGATTCCCCGGGACATGGCCCTGAG
GATCCTGGTCAAACTGACGGAACTGGAAACGGACCCGCTCGGCTTCCGCACCACGGCGCTCGTCTCCCGGCCCGACCGGC
GCCGGCTCCGTGTCGGCGACTACCGCGTCATCTACACGATCGACAACGGCGAGTTGACGGTCTGGGTCGTTCATGTCGGA
CACCGCTCCACGGTATACGACACCTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13826.54 Da        Isoelectric Point: 4.2870

>AT181808 WP_004236473.1 NZ_CP064833:c725445-725086 [Morganella morganii subsp. morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNYWVNDLASDSNLKLNELLGYIADVAWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp

>AT181808 NZ_CP086177:3241953-3242219 [Streptomyces fungicidicus]
ATGACCGAGATGCCCATAGAGTCCATTCGTGACGTGCGCGCCCACCTGGCCGAGGTGGTCGAACGGGCGGACCGGGACGA
CACGCCCACGGTCATCACCCGGCGAGGCAAGCAGGTGGCCGCAGTCGTGTCGATGGAGGTCCTTCGCAAGTACCAGGAAT
GGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCGAACCCGGCAGCCGGTATCCCGATCGAGGACGTCATG
CGGGAGACGCTGGAGCGCGGTGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2RCL2

Antitoxin

Source ID Structure
AlphaFold DB J7U1S9

References